Evidence map›Paper›PMID 34641706›Full record

Trial reportThyroid : official journal of the American Thyroid Association2022

Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans.

Alexandra M Dumitrescu, Erin C Hanlon, Marilyn Arosemena, Olga Duchon, Matthew Ettleson, Mihai Giurcanu, Antonio C Bianco

Open access · greenAbstract readClinical Trial, Phase IRandomized Controlled Trial
In one paragraph

Trial report in Thyroid : official journal of the American Thyroid Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Optimizing the treatment of hypothyroidism.Nature reviews. Endocrinology · 2024
    Article
  5. Emerging Therapies in Hypothyroidism.Annual review of medicine · 2024
    Review
  6. Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2023
    Review
  7. Review
  8. Review
  9. The relevance of TThe lancet. Diabetes & endocrinology · 2022
    Review
  10. Optimal Thyroid Hormone Replacement.Endocrine reviews · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Alexandra M DumitrescuSection of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Chicago, Illinois, USA.ORCID 0000-0002-2743-770X
Erin C HanlonSection of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Chicago, Illinois, USA.
Marilyn ArosemenaSection of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Chicago, Illinois, USA.
Olga DuchonSection of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Chicago, Illinois, USA.
Matthew EttlesonSection of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Chicago, Illinois, USA.ORCID 0000-0003-0328-1752
Mihai GiurcanuDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Antonio C BiancoSection of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Chicago, Illinois, USA.ORCID 0000-0001-7737-6813
Diabetes Australia · AUChicago Department of Public Health · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
INTERGRATED CLINICAL AND BASIC ENDOCRINOLOGY RESEARCHT32DK007011 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 1986 to 2026
$5.8M
Proof of Extended Absorption of Liothyronine from PolyZincLiothyronine (PZL) inHumansR44DK116396 · NIDDK · SYNTHONICS, INC. · PI PICCARIELLO, THOMAS · 2019 to 2020
$2.0M
NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R44 DK116396NIDDK NIH HHS T32 DK007011
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAdultDouble-Blind MethodDrug Therapy, CombinationFemaleHormone Replacement TherapyHumansHypothyroidismMaleMiddle AgedTriiodothyronineYoung AdultZincTriiodothyronineZinchypothyroidismliothyroninemetal coordinationslow releasethyroidthyroxine

Identifiers

PMID34641706
PMCPMC8861912
OpenAlexW3207590171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.