Evidence map›Paper›PMID 34641594›Full record

ArticleMolecules (Basel, Switzerland)2021

Curcumin Loaded Dendrimers Specifically Reduce Viability of Glioblastoma Cell Lines.

John Gallien, Bhairavi Srinageshwar, Kellie Gallo, Gretchen Holtgrefe, Sindhuja Koneru, Paulina Sequeiros Otero, Catalina Alvarez Bueno, Jamie Mosher, Alison Roh, D Stave Kohtz and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
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  5. Cancer chemoprevention: signaling pathways and strategic approaches.Signal transduction and targeted therapy · 2025
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  14. Curcumin nanoparticles in heat stroke management.Journal of nanobiotechnology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

John GallienField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Bhairavi SrinageshwarField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.ORCID 0000-0002-8763-545X
Kellie GalloField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Gretchen HoltgrefeDepartment of Chemistry and Biochemistry, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Sindhuja KoneruField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Paulina Sequeiros OteroField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Catalina Alvarez BuenoField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Jamie MosherDepartment of Chemistry and Biochemistry, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Alison RohDepartment of Chemistry and Biochemistry, Central Michigan University, Mt. Pleasant, MI 48859, USA.
D Stave KohtzProgram in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Douglas SwansonDepartment of Chemistry and Biochemistry, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Ajit SharmaDepartment of Chemistry and Biochemistry, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Gary DunbarField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Julien RossignolField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.ORCID 0000-0002-8662-0547
Central Michigan University · US

Funding

Non-Invasive Nanoparticle Platform for Tool Delivery to the BrainR21EY030012 · NEI · CENTRAL MICHIGAN UNIVERSITY · PI HOCHGESCHWENDER, UTE H, ROSSIGNOL, JULIEN · 2019 to 2019
$520k
NEI NIH HHS R21 EY030012
6 · The paper itself

Abstract

Glioblastoma (GB) is a deadly and aggressive cancer of the CNS. Even with extensive resection and chemoradiotherapy, patient survival is still only 15 months. To maintain growth and proliferation, cancer cells require a high oxidative state. Curcumin, a well-known anti-inflammatory antioxidant, is a potential candidate for treatment of GB. To facilitate efficient delivery of therapeutic doses of curcumin into cells, we encapsulated the drug in surface-modified polyamidoamine (PAMAM) dendrimers. We studied the

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorCell SurvivalCurcuminDendrimersDrug CarriersFemaleGlioblastomaHumansMaleMiceMice, Inbred C57BLPolyaminesRatsRats, Sprague-DawleyAntineoplastic AgentsCurcuminDendrimersDrug CarriersPoly(amidoamine)Polyaminescancercurcuminglioblastomanano-moleculePAMAM dendrimerstherapytoxicology

Identifiers

PMID34641594
PMCPMC8512379
OpenAlexW3205789881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.