ArticleMolecules (Basel, Switzerland)2021
New Methods for the Synthesis of Spirocyclic Cephalosporin Analogues.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Synthesis of Novel 3-spirocephalosporins and Evaluation of their Antibacterial Activity.Current organic synthesis · 2025Article
- Exploring the Reactivity of Rigid 1-Azadienes Derived from Methylene γ-Lactams. Applications to the Stereoselective Synthesis of Spiro-γ-Lactams.The Journal of organic chemistry · 2024Article
- Isocyanide-based synthesis of spirorhodanine-cyclopentadiene and spirorhodanine-iminobutenolide conjugates from Winterfeldt's zwitterions and 5-ylidene rhodanines.Molecular diversity · 2024Article
- New Synthetic Methodology for Drug-like Molecules.Molecules (Basel, Switzerland) · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
Spiro compounds provide attractive targets in drug discovery due to their inherent three-dimensional structures, which enhance protein interactions, aid solubility and facilitate molecular modelling. However, synthetic methodology for the spiro-functionalisation of important classes of penicillin and cephalosporin β-lactam antibiotics is comparatively limited. We report a novel method for the generation of spiro-cephalosporin compounds through a Michael-type addition to the dihydrothiazine ring. Coupling of a range of catechols is achieved under mildly basic conditions (K
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