Evidence map›Paper›PMID 34641576›Full record

ArticleMolecules (Basel, Switzerland)2021

Integrated Network Pharmacology Analysis and

Huihai Yang, Man-Kit Cheung, Grace Gar-Lee Yue, Ping-Chung Leung, Chun-Kwok Wong, Clara Bik-San Lau

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Article
  4. CanFrontiers in pharmacology · 2026
    Article
  5. Article
  6. Pharmacological role ofWorld journal of gastrointestinal oncology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Huihai YangInstitute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.ORCID 0000-0002-9986-7362
Man-Kit CheungDepartment of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.ORCID 0000-0002-2764-2113
Grace Gar-Lee YueInstitute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Ping-Chung LeungInstitute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.ORCID 0000-0002-0195-4688
Chun-Kwok WongInstitute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.ORCID 0000-0002-5637-8331
Clara Bik-San LauInstitute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.ORCID 0000-0002-7409-1270
Chinese University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herba Patriniae (HP) are medicinal plants commonly used in colorectal cancer (CRC) patients. In this study, network pharmacology was used to predict the active components and key signaling pathways of HP in CRC.

Indexed as

AdenocarcinomaAntineoplastic AgentsCell MovementColorectal NeoplasmsDipeptidesDrug DiscoveryDrugs, Chinese HerbalErbB ReceptorsForkhead Box Protein O1Gene Expression Regulation, NeoplasticHCT116 CellsHumansMedicine, Chinese TraditionalPatriniaPlant ExtractsPlants, MedicinalAntineoplastic AgentsDipeptidesDrugs, Chinese HerbalEGFR protein, humanErbB ReceptorsForkhead Box Protein O1FOXO1 protein, humanN-benzoylphenylalanylphenylalinol acetatePlant Extractscolorectal cancerCRCErbB signaling pathwayFoxO signaling pathwayHerba Patriniaenetwork pharmacologyPatrinia heterophylla

Identifiers

PMID34641576
PMCPMC8513027
OpenAlexW3201726963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.