Evidence map›Paper›PMID 34641548›Full record

ArticleMolecules (Basel, Switzerland)2021

Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors.

Anusree Venkidath, Jong Min Oh, Sanal Dev, Elham Amin, Shebina P Rasheed, Ajeesh Vengamthodi, Nicola Gambacorta, Ahmed Khames, Mohamed A Abdelgawad, Ginson George and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Anusree VenkidathCentre for Experimental Drug Design and Development, Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna 679325, India.
Jong Min OhDepartment of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
Sanal DevCentre for Experimental Drug Design and Development, Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna 679325, India.ORCID 0000-0002-4128-8413
Elham AminDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah 52571, Saudi Arabia.ORCID 0000-0002-7190-3974
Shebina P RasheedCentre for Experimental Drug Design and Development, Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna 679325, India.ORCID 0000-0001-7882-8412
Ajeesh VengamthodiCentre for Experimental Drug Design and Development, Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna 679325, India.
Nicola GambacortaDipartimento di Farmacia-Scienze del Farmaco, Università Degli Studi di Bari "Aldo Moro", Via E. Orabona, 4, I-70125 Bari, Italy.ORCID 0000-0003-1965-1519
Ahmed KhamesDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0001-7917-975X
Mohamed A AbdelgawadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.ORCID 0000-0001-9035-5638
Ginson GeorgeDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682041, India.ORCID 0000-0002-7131-2496
Orazio NicolottiDipartimento di Farmacia-Scienze del Farmaco, Università Degli Studi di Bari "Aldo Moro", Via E. Orabona, 4, I-70125 Bari, Italy.ORCID 0000-0001-6533-5539
Hoon KimDepartment of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.ORCID 0000-0002-7203-3712
Bijo MathewDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682041, India.
Amrita Vishwa Vidyapeetham · INSunchon National University · KRUniversity of Bari Aldo Moro · ITBeni-Suef University · EGJouf University · SATaif University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A small series of nitro group-bearing enamides was designed, synthesized (

Indexed as

AmidesAmyloid Precursor Protein SecretasesBlood-Brain BarrierMembranes, ArtificialMolecular StructureMonoamine OxidaseMonoamine Oxidase InhibitorsProtease InhibitorsAmidesAmyloid Precursor Protein SecretasesMembranes, ArtificialMonoamine OxidaseMonoamine Oxidase InhibitorsProtease Inhibitorsdual-acting inhibitormolecular dockingmonoamine oxidasenitro group-bearing enamidespotent reversible inhibitorβ-secretase

Identifiers

PMID34641548
PMCPMC8512054
OpenAlexW3201909234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.