Evidence map›Paper›PMID 34641543›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives.

Annita Katopodi, Evangelia Tsotsou, Triantafylia Iliou, Georgia-Eirini Deligiannidou, Eleni Pontiki, Christos Kontogiorgis, Fotios Tsopelas, Anastasia Detsi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  12. Antioxidant Activity of Coumarins and Their Metal Complexes.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Annita KatopodiLaboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, 15780 Athens, Greece.
Evangelia TsotsouLaboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, 15780 Athens, Greece.
Triantafylia IliouLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Georgia-Eirini DeligiannidouLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-3976-4473
Eleni PontikiLaboratory of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Christos KontogiorgisLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0001-7835-8246
Fotios TsopelasLaboratory of Inorganic and Analytical Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, 15780 Athens, Greece.ORCID 0000-0001-6917-2028
Anastasia DetsiLaboratory of Organic Chemistry, Department of Chemical Sciences, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, 15780 Athens, Greece.ORCID 0000-0001-8325-2980
National Technical University of Athens · GRDemocritus University of Thrace · GRAristotle University of Thessaloniki · GR

Funding

State Scholarships Foundation
6 · The paper itself

Abstract

A series of novel multi-substituted coumarin derivatives were synthesized, spectroscopically characterized, and evaluated for their antioxidant activity, soybean lipoxygenase (LOX) inhibitory ability, their influence on cell viability in immortalized human keratinocytes (HaCaT), and cytotoxicity in adenocarcinomic human alveolar basal epithelial cells (A549) and human melanoma (A375) cells, in vitro. Coumarin analogues

Indexed as

A549 CellsAntioxidantsBiomimeticsBlood ProteinsCell SurvivalCoumarinsFluoresceinsFluorescent DyesFree Radical ScavengersGlycine maxHumansKeratinocytesLipoxygenase InhibitorsMolecular Docking SimulationAntioxidantsBlood ProteinsCoumarinsdiacetyldichlorofluoresceinFluoresceinsFluorescent DyesFree Radical ScavengersLipoxygenase Inhibitorsantioxidant activitybiomimetic chromatographycoumarinscytotoxicitylipoxygenase inhibitionmolecular docking

Identifiers

PMID34641543
PMCPMC8512853
OpenAlexW3204067852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.