Evidence map›Paper›PMID 34641533›Full record

ArticleMolecules (Basel, Switzerland)2021

Photodynamic Therapy with Tumor Cell Discrimination through RNA-Targeting Ability of Photosensitizer.

Yuan Xu, Yang Tan, Xiuqin Ma, Xiaoyi Jin, Ye Tian, Miao Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuan XuCollege of Marine Technology and Environment, Dalian Ocean University, Dalian 116023, China.
Yang TanSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116023, China.
Xiuqin MaSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116023, China.
Xiaoyi JinSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116023, China.
Ye TianCollege of Marine Technology and Environment, Dalian Ocean University, Dalian 116023, China.ORCID 0000-0002-9750-7777
Miao LiSchool of Biological Engineering, Dalian Polytechnic University, Dalian 116023, China.
Dalian Polytechnic University · CNDalian Ocean University · CN

Funding

Key R&D Program of Guangdong Province 2019B020215001National Natural Science Foundation of China 22108024 and 31901775Science & Technology Department Funding for scientific research of Liaoning province 2021-BS-226
6 · The paper itself

Abstract

Photodynamic therapy (PDT) represents an effective treatment to cure cancer. The targeting ability of the photosensitizer is of utmost importance. Photosensitizers that discriminate cancer cells can avoid the killing of normal cells and improve PDT efficacy. However, the design and synthesis of photosensitizers conjugated with a recognition unit of cancer cell markers is complex and may not effectively target cancer. Considering that the total RNA content in cancer cells is commonly higher than in normal cells, this study has developed the photosensitizer

Indexed as

AnimalsCell Line, TumorChlorocebus aethiopsCOS CellsFemaleHumansInjections, IntravenousLow-Level Light TherapyMCF-7 CellsMiceMice, Inbred BALB CMolecular Targeted TherapyNeoplasmsPhotochemotherapyPhotosensitizing AgentsRNAPhotosensitizing AgentsRNAcancer cell discriminationcyanine dyesphotosensitizerRNA targeting

Identifiers

PMID34641533
PMCPMC8512109
OpenAlexW3204311846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.