Evidence map›Paper›PMID 34641528›Full record

ArticleMolecules (Basel, Switzerland)2021

Cannabinoid Receptor 2 Alters Social Memory and Microglial Activity in an Age-Dependent Manner.

Joanna Agnieszka Komorowska-Müller, Tanushka Rana, Bolanle Fatimat Olabiyi, Andreas Zimmer, Anne-Caroline Schmöle

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Essential Oils fromCurrent pharmaceutical biotechnology · 2026
    Article
  3. Ageing, Neurodegeneration and the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joanna Agnieszka Komorowska-MüllerInstitute for Molecular Psychiatry, Medical Faculty, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-9063-2495
Tanushka RanaInstitute for Molecular Psychiatry, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Bolanle Fatimat OlabiyiInstitute for Molecular Psychiatry, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Andreas ZimmerInstitute for Molecular Psychiatry, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Anne-Caroline SchmöleInstitute for Molecular Psychiatry, Medical Faculty, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0001-7091-6354
University of Bonn · DE

Funding

Deutsche Forschungsgemeinschaft EXC2151 - 390873048
6 · The paper itself

Abstract

Physiological brain aging is characterized by gradual, substantial changes in cognitive ability, accompanied by chronic activation of the neural immune system. This form of inflammation, termed inflammaging, in the central nervous system is primarily enacted through microglia, the resident immune cells. The endocannabinoid system, and particularly the cannabinoid receptor 2 (CB

Indexed as

AgingAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticAnxietyBehavior, AnimalCD68 MoleculeHippocampusLipofuscinMaleMemoryMiceMice, Inbred C57BLMicrogliaMorris Water Maze TestNeuronsAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeCD68 protein, mouseLipofuscinReceptor, Cannabinoid, CB2cannabinoid receptor 2 (CB2R)inflammaginglipofuscinmemorymicroglia

Identifiers

PMID34641528
PMCPMC8513097
OpenAlexW3203287617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.