Evidence map›Paper›PMID 34641518›Full record

ArticleMolecules (Basel, Switzerland)2021

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in

Irene Gonzalez-Jimenez, Jose Lucio, Alejandra Roldan, Laura Alcazar-Fuoli, Emilia Mellado

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Directed evolution of the pathogenic moldAntimicrobial agents and chemotherapy · 2026
    Article
  4. Understanding multi-azole resistance inFrontiers in fungal biology · 2026
    Article
  5. Pathogenesis and Triazole Resistance inInfection and drug resistance · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Transcriptomic and metabolomic analysis of a non-Frontiers in microbiology · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Microbiology spectrum · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Irene Gonzalez-JimenezMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII), 28220 Majadahonda, Madrid, Spain.ORCID 0000-0003-4821-4852
Jose LucioMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII), 28220 Majadahonda, Madrid, Spain.ORCID 0000-0002-7545-7510
Alejandra RoldanMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII), 28220 Majadahonda, Madrid, Spain.
Laura Alcazar-FuoliMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII), 28220 Majadahonda, Madrid, Spain.
Emilia MelladoMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III (ISCIII), 28220 Majadahonda, Madrid, Spain.ORCID 0000-0002-9801-0260
Instituto de Salud Carlos III · ES

Funding

Instituto de Salud Carlos III FIS PI18/CIII/00045Instituto de Salud Carlos III REIPI RD16/CIII/0004/0003
6 · The paper itself

Abstract

Invasive aspergillosis, mainly caused by

Indexed as

Antifungal AgentsAspergillosisAspergillus fumigatusAzolesCytochrome P-450 Enzyme SystemDrug Resistance, FungalFungal ProteinsGene Expression Regulation, FungalHumansHydroxymethylglutaryl CoA ReductasesMicrobial Sensitivity TestsPoint MutationPromoter Regions, GeneticWhole Genome SequencingAntifungal AgentsAzolescytochrome P-450 CYP51A, Aspergilluscytochrome P-450 CYP51B, AspergillusCytochrome P-450 Enzyme SystemFungal ProteinsHydroxymethylglutaryl CoA ReductasesAspergillus fumigatusazole resistance mechanismscyp51Ahmg1hmg2

Identifiers

PMID34641518
PMCPMC8512156
OpenAlexW3203958356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.