Evidence map›Paper›PMID 34641507›Full record

ArticleMolecules (Basel, Switzerland)2021

TEMPO/TCC as a Chemo Selective Alternative for the Oxidation of Hyaluronic Acid.

Junwen Shan, Thomas Böck, Thorsten Keller, Leonard Forster, Torsten Blunk, Jürgen Groll, Jörg Teßmar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Junwen ShanDepartment of Functional Materials in Medicine and Dentistry, Bavarian Polymer Institute (BPI), University of Würzburg, 297070 Würzburg, Germany.
Thomas BöckDepartment of Functional Materials in Medicine and Dentistry, Bavarian Polymer Institute (BPI), University of Würzburg, 297070 Würzburg, Germany.
Thorsten KellerDepartment of Functional Materials in Medicine and Dentistry, Bavarian Polymer Institute (BPI), University of Würzburg, 297070 Würzburg, Germany.ORCID 0000-0002-2897-5761
Leonard ForsterDepartment of Functional Materials in Medicine and Dentistry, Bavarian Polymer Institute (BPI), University of Würzburg, 297070 Würzburg, Germany.
Torsten BlunkDepartment of Trauma, Hand, Plastic and Reconstructive Surgery, University of Würzburg, Oberdürrbacher Str. 6, 97080 Würzburg, Germany.
Jürgen GrollDepartment of Functional Materials in Medicine and Dentistry, Bavarian Polymer Institute (BPI), University of Würzburg, 297070 Würzburg, Germany.ORCID 0000-0003-3167-8466
Jörg TeßmarDepartment of Functional Materials in Medicine and Dentistry, Bavarian Polymer Institute (BPI), University of Würzburg, 297070 Würzburg, Germany.ORCID 0000-0001-7057-5369
University of Würzburg · DE

Funding

Deutsche Forschungsgemeinschaft 326998133European Regional Development Fund
6 · The paper itself

Abstract

Hyaluronic acid (HA)-based hydrogels are very commonly applied as cell carriers for different approaches in regenerative medicine. HA itself is a well-studied biomolecule that originates from the physiological extracellular matrix (ECM) of mammalians and, due to its acidic polysaccharide structure, offers many different possibilities for suitable chemical modifications which are necessary to control, for example, network formation. Most of these chemical modifications are performed using the free acid function of the polymer and, additionally, lead to an undesirable breakdown of the biopolymer's backbone. An alternative modification of the vicinal diol of the glucuronic acid is oxidation with sodium periodate to generate dialdehydes via a ring opening mechanism that can subsequently be further modified or crosslinked via Schiff base chemistry. Since this oxidation causes a structural destruction of the polysaccharide backbone, it was our intention to study a novel synthesis protocol frequently applied to selectively oxidize the C6 hydroxyl group of saccharides. On the basis of this TEMPO/TCC oxidation, we studied an alternative hydrogel platform based on oxidized HA crosslinked using adipic acid dihydrazide as the crosslinker.

Indexed as

AdipatesCell DifferentiationCell SurvivalChondrogenesisCross-Linking ReagentsCyclic N-OxidesElastic ModulusHumansHyaluronan ReceptorsHyaluronic AcidHydrogelsMesenchymal Stem CellsOxidation-ReductionSchiff BasesSurface Plasmon ResonanceAdipatesadipic dihydrazideCD44 protein, humanCross-Linking ReagentsCyclic N-OxidesHyaluronan ReceptorsHyaluronic AcidHydrogelsSchiff BasesTEMPOhyaluronic acidhydrogel formationoxidationSchiff base chemistry

Identifiers

PMID34641507
PMCPMC8512827
OpenAlexW3203834082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.