β-Cyclodextrin Derivative Grafted on Silica Gel Represents a New Polymeric Sorbent for Extracting Nitisinone from Model Physiological Fluids.

Magdalena Danek, Anna Korytkowska-Wałach, Hanna Barchańska

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Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

0.1field-weighted citation impact, top 44% of its field

1 · What the graph read from it

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5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Magdalena DanekDepartment of Inorganic Chemistry, Analytical Chemistry and Electrochemistry, Faculty of Chemistry, Silesian University of Technology, B. Krzywoustego 6 St., 44-100 Gliwice, Poland.

Anna Korytkowska-WałachDepartment of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, B. Krzywoustego 4 St., 44-100 Gliwice, Poland.

Hanna BarchańskaDepartment of Inorganic Chemistry, Analytical Chemistry and Electrochemistry, Faculty of Chemistry, Silesian University of Technology, B. Krzywoustego 6 St., 44-100 Gliwice, Poland.

Silesian University of Technology · PL

Funding

This work was supported by the Excellence Initiative - Research University program implemented at the Silesian University of Technology, 2021. RN/72/20/21

6 · The paper itself

Abstract

Nitisinone (NTBC) is used in the treatment of disorders affecting the tyrosine pathway, including hereditary tyrosinemia type I, alkaptonuria, and neuroblastoma. An inappropriate dosage of this therapeutic drug causes side effects; therefore, it is necessary to develop a rapid and sensitive method to monitor the content of NTBC in patients' blood. This study aimed to develop anew polymeric sorbent containing β-cyclodextrin (β-CD) derivatives grafted on silica gel to effectively extract NTBC from model physiological fluids. The inclusion complex formed between β-CD and NTBC was examined by proton nuclear magnetic resonance spectroscopy. The novel sorbents with derivatives of β-CD were prepared on modified silica gel using styrene as a comonomer, ethylene glycol dimethacrylate as a crosslinking agent, and 2,2'-azo-bis-isobutyronitrile as a polymerization initiator. The obtained products were characterized via Fourier transform infrared spectroscopy and then used as sorbents as part of a solid phase extraction technique. High NTBC recovery (70%indicated that the developed polymeric sorbent may be suitable for extracting this compound from patients' blood samples.

Indexed as

Adsorptionbeta-CyclodextrinsCyclohexanonesEnzyme InhibitorsHumansNitrobenzoatesPolymerizationPolymersSilica GelSilicon DioxideSolid Phase Extractionbeta-CyclodextrinsCyclohexanonesEnzyme InhibitorsnitisinoneNitrobenzoatesPolymersSilica GelSilicon DioxideFourier transform infrared spectroscopyliquid chromatographymodel physiological fluidsnitisinonenuclear magnetic resonancesolid phase extractionβ-cyclodextrin

Identifiers

PMID34641489

DOI10.3390/molecules26195945

PMCPMC8512355

OpenAlexW3205413621

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.