Evidence map›Paper›PMID 34641326›Full record

ReviewMolecules (Basel, Switzerland)2021

The Relationship of Glutathione-

Tiffany M Russell, Mahan Gholam Azad, Des R Richardson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tiffany M RussellCentre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.
Mahan Gholam AzadCentre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.
Des R RichardsonCentre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.

Funding

National Health and Medical Research Council APP1159596
6 · The paper itself

Abstract

Nitric oxide is a diatomic gas that has traditionally been viewed, particularly in the context of chemical fields, as a toxic, pungent gas that is the product of ammonia oxidation. However, nitric oxide has been associated with many biological roles including cell signaling, macrophage cytotoxicity, and vasodilation. More recently, a model for nitric oxide trafficking has been proposed where nitric oxide is regulated in the form of dinitrosyl-dithiol-iron-complexes, which are much less toxic and have a significantly greater half-life than free nitric oxide. Our laboratory has previously examined this hypothesis in tumor cells and has demonstrated that dinitrosyl-dithiol-iron-complexes are transported and stored by multi-drug resistance-related protein 1 and glutathione-

Indexed as

ATP-Binding Cassette, Sub-Family C ProteinsBinding SitesBiological TransportGene Expression Regulation, NeoplasticGlutathione S-Transferase piHumansNeoplasmsNitric OxideSignal TransductionATP-Binding Cassette, Sub-Family C ProteinsGlutathione S-Transferase piGSTP1 protein, humanmultidrug resistance-associated protein 1Nitric Oxidedinitrosyl–dithiol iron complexesfree radicalsglutathione-S-transferasemulti-drug resistance related protein 1nitric oxidenitric oxide synthasenitrogen monoxideprotein metal ion interactionsvasodilation

Identifiers

PMID34641326
PMCPMC8510172

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.