Evidence map›Paper›PMID 34641312›Full record

ReviewMolecules (Basel, Switzerland)2021

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review.

Florence Nwakaego Mbaoji, Justus Amuche Nweze, Liyan Yang, Yangbin Huang, Shushi Huang, Akachukwu Marytheresa Onwuka, Ikechukwu Emmanuel Peter, Cynthia Chioma Mbaoji, Mingguo Jiang, Yunkai Zhang and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  7. Review
  8. Review
  9. 5-Molecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Florence Nwakaego MbaojiGuangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.
Justus Amuche NwezeGuangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.ORCID 0000-0003-3481-040X
Liyan YangGuangxi Biomass Industrialization Engineering Institute, National Engineering Research Center of Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass, Guangxi Academy of Sciences, Nanning 530007, China.
Yangbin HuangGuangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.
Shushi HuangGuangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.
Akachukwu Marytheresa OnwukaDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.ORCID 0000-0002-8282-5983
Ikechukwu Emmanuel PeterDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.ORCID 0000-0003-1223-582X
Cynthia Chioma MbaojiDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.ORCID 0000-0002-1449-7906
Mingguo JiangGuangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Marine Sciences and Biotechnology, Guangxi University for Nationalities, Nanning 530008, China.
Yunkai ZhangCollege of Life Science and Technology of Guangxi University, Nanning 530004, China.
Lixia PanGuangxi Biomass Industrialization Engineering Institute, National Engineering Research Center of Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass, Guangxi Academy of Sciences, Nanning 530007, China.
Dengfeng YangGuangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.ORCID 0000-0003-0596-6157
Guangxi Academy of Sciences · CNUniversity of Nigeria · NGGuangxi University · CNGuangxi University for Nationalities · CN

Funding

National Natural Science Foundation of China 31660251, 31860245 and 31960203Natural Science Foundation of Guangxi Province 2017GXNSFAA198010, 2018GXNSFAA138024 and 2018GXNSFAA281019Special Project for the Base of Guangxi Science and Technology and Talents AD17129019the central government direct special funds for local science and technology development projects ZY1949015
6 · The paper itself

Abstract

Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. It is a long-term illness that affects both young and old people. In recent years, significant attempts have been made to identify new anticancer drugs, as the existing drugs have been useless due to resistance of the malignant cells. Natural products derived from marine sources have been tested for their anticancer activity using a variety of cancer cell lines derived from humans and other sources, some of which have already been approved for clinical use, while some others are still being tested. These compounds can assault cancer cells via a variety of mechanisms, but certain cancer cells are resistant to them. As a result, the goal of this review was to look into the anticancer potential of marine natural products or their derivatives that were isolated from January 2019 to March 2020, in cancer cell lines, with a focus on the class and type of isolated compounds, source and location of isolation, cancer cell line type, and potency (IC

Indexed as

AnimalsAntineoplastic AgentsAquatic OrganismsBiological ProductsCell Line, TumorCell ProliferationCell SurvivalHumansNeoplasmsSecondary MetabolismAntineoplastic AgentsBiological Productscancercancer cell linedrug developmentlead optimizationmarine secondary metabolites

Identifiers

PMID34641312
PMCPMC8510081
OpenAlexW3202819898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.