Evidence map›Paper›PMID 34641215›Full record

ArticlePolymers2021

Poly-ε-Caprolactone/Fibrin-Alginate Scaffold: A New Pro-Angiogenic Composite Biomaterial for the Treatment of Bone Defects.

Jiongyu Ren, Nupur Kohli, Vaibhav Sharma, Taleen Shakouri, Zalike Keskin-Erdogan, Siamak Saifzadeh, Gary I Brierly, Jonathan C Knowles, Maria A Woodruff, Elena García-Gareta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jiongyu RenFaculty of Engineering, Queensland University of Technology, Brisbane, QLD 4059, Australia.ORCID 0000-0001-5661-5723
Nupur KohliRegenerative Biomaterials Group, The RAFT Institute & The Griffin Institute, Northwick Park & Saint Mark's Hospital, London HA1 3UJ, UK.
Vaibhav SharmaRegenerative Biomaterials Group, The RAFT Institute & The Griffin Institute, Northwick Park & Saint Mark's Hospital, London HA1 3UJ, UK.
Taleen ShakouriDivision of Biomaterials & Tissue Engineering, Eastman Dental Institute, University College London, Rowland Hill Street, London NW3 2PF, UK.ORCID 0000-0003-0356-1527
Zalike Keskin-ErdoganDivision of Biomaterials & Tissue Engineering, Eastman Dental Institute, University College London, Rowland Hill Street, London NW3 2PF, UK.
Siamak SaifzadehMedical Engineering Research Facility, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Gary I BrierlyFaculty of Engineering, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Jonathan C KnowlesDivision of Biomaterials & Tissue Engineering, Eastman Dental Institute, University College London, Rowland Hill Street, London NW3 2PF, UK.ORCID 0000-0003-3917-3446
Maria A WoodruffFaculty of Engineering, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Elena García-GaretaRegenerative Biomaterials Group, The RAFT Institute & The Griffin Institute, Northwick Park & Saint Mark's Hospital, London HA1 3UJ, UK.ORCID 0000-0001-7062-9099
Queensland University of Technology · AUSt Mark's Hospital · GBUniversity College London · GB

Funding

Australian Research Council LP130100461RAFT Charitable Funds
6 · The paper itself

Abstract

We hypothesized that a composite of 3D porous melt-electrowritten poly-ɛ-caprolactone (PCL) coated throughout with a porous and slowly biodegradable fibrin/alginate (FA) matrix would accelerate bone repair due to its angiogenic potential. Scanning electron microscopy showed that the open pore structure of the FA matrix was maintained in the PCL/FA composites. Fourier transform infrared spectroscopy and differential scanning calorimetry showed complete coverage of the PCL fibres by FA, and the PCL/FA crystallinity was decreased compared with PCL. In vitro cell work with osteoprogenitor cells showed that they preferentially bound to the FA component and proliferated on all scaffolds over 28 days. A chorioallantoic membrane assay showed more blood vessel infiltration into FA and PCL/FA compared with PCL, and a significantly higher number of bifurcation points for PCL/FA compared with both FA and PCL. Implantation into a rat cranial defect model followed by microcomputed tomography, histology, and immunohistochemistry after 4- and 12-weeks post operation showed fast early bone formation at week 4, with significantly higher bone formation for FA and PCL/FA compared with PCL. However, this phenomenon was not extrapolated to week 12. Therefore, for long-term bone regeneration, tuning of FA degradation to ensure syncing with new bone formation is likely necessary.

Indexed as

alginateangiogenesisbone regenerationfibrinpolycaprolactone

Identifiers

PMID34641215
PMCPMC8512525
OpenAlexW3203007543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.