ArticlePolymers2021
A Novel Green Preparation of Ag/RGO Nanocomposites with Highly Effective Anticancer Performance.
Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 69 citations in OpenAlex.
- Quercetin Released Biomedical Hybrid Hydrogels Fabricated by Silk Fibroin and Sodium Alginate with Incorporation of Ag@rGO Nanosheets.Molecules (Basel, Switzerland) · 2026Article
- Innovative self-assembled silver nanoparticles on reduced graphene oxide hydrogel nanocomposite for improved electrochemical hydrogen generation and sensing.Scientific reports · 2025Article
- Hemocompatible gelatin-glycidyl methacrylate/graphene oxide composite hydrogels for vascular catheter applications.Scientific reports · 2025Article
- Bio-inspired preparation of Ag NPs, rGO, and Ag/rGO nanocomposites for acoustical, antioxidant, and plant growth regulatory studies.Scientific reports · 2025Article
- Ag-NP-Decorated Carbon Nanostructures: Synthesis, Characterization, and Antimicrobial Properties.ACS omega · 2024Article
- Synthesis of a Ag/rGO nanocomposite usingRSC advances · 2022Article
- Facile Green Synthesis of Ni(OH)Molecules (Basel, Switzerland) · 2022Article
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- Structural Characterization of DegradedPolymers · 2022Article
- Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles.International journal of molecular sciences · 2022Article
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- Transferrin-Modified Mangiferin-Loaded SLNs: Preparation, Characterization, and Application in A549 Lung Cancer Cell.Drug design, development and therapy · 2022Article
- Development of mucus-penetrating iodine loaded self-emulsifying system for local vaginal delivery.PloS one · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The efficacy of current cancer therapies is limited due to several factors, including drug resistance and non-specific toxic effects. Due to their tuneable properties, silver nanoparticles (Ag NPs) and graphene derivative-based nanomaterials are now providing new hope to treat cancer with minimum side effects. Here, we report a simple, inexpensive, and eco-friendly protocol for the preparation of silver-reduced graphene oxide nanocomposites (Ag/RGO NCs) using orange peel extract. This work was planned to curtail the use of toxic chemicals, and improve the anticancer performance and cytocompatibility of Ag/RGO NCs. Aqueous extract of orange peels is abundant in phytochemicals that act as reducing and stabilizing agents for the green synthesis of Ag NPs and Ag/RGO NCs from silver nitrate and graphene oxide (GO). Moreover, the flavonoid present in orange peel is a potent anticancer agent. Green-prepared Ag NPs and Ag/RGO NCs were characterized by UV-visible spectrophotometry, transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and dynamic light scattering (DLS). The results of the anticancer study demonstrated that the killing potential of Ag/RGO NCs against human breast cancer (MCF7) and lung cancer (A549) cells was two-fold that of pure Ag NPs. Moreover, the cytocompatibility of Ag/RGO NCs in human normal breast epithelial (MCF10A) cells and normal lung fibroblasts (IMR90) was higher than that of pure Ag NPs. This mechanistic study indicated that Ag/RGO NCs induce toxicity in cancer cells through pro-oxidant reactive oxygen species generation and antioxidant glutathione depletion and provided a novel green synthesis of Ag/RGO NCs with highly effective anticancer performance and better cytocompatibility.
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