Evidence map›Paper›PMID 34641162›Full record

ArticlePolymers2021

Chitosan-Coated 5-Fluorouracil Incorporated Emulsions as Transdermal Drug Delivery Matrices.

Taif Ali Khan, Abul Kalam Azad, Shivkanya Fuloria, Asif Nawaz, Vetriselvan Subramaniyan, Muhammad Akhlaq, Muhammad Safdar, Kathiresan V Sathasivam, Mahendran Sekar, Omji Porwal and 5 more

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Therapeutic Application ofMedicina (Kaunas, Lithuania) · 2022
    Article
  8. Polysaccharide-Based Transdermal Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 5 countries.

Taif Ali KhanFaculty of Pharmacy, Gomal University, Dera Ismail Khan 29050, Pakistan.
Abul Kalam AzadAdvanced Drug Delivery Laboratory, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang, Malaysia.ORCID 0000-0003-4874-1169
Shivkanya FuloriaFaculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia.
Asif NawazFaculty of Pharmacy, Gomal University, Dera Ismail Khan 29050, Pakistan.ORCID 0000-0002-3232-0258
Vetriselvan SubramaniyanFaculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP 2, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia.ORCID 0000-0002-9629-9494
Muhammad AkhlaqFaculty of Pharmacy, Gomal University, Dera Ismail Khan 29050, Pakistan.
Muhammad SafdarFaculty of Pharmacy, Gomal University, Dera Ismail Khan 29050, Pakistan.
Kathiresan V SathasivamCentre of Excellence for Biomaterials and Engineering, AIMST University, Bedong 08100, Kedah, Malaysia.
Mahendran SekarDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh 30450, Perak, Malaysia.ORCID 0000-0002-3022-6137
Omji PorwalDepartment of Pharmacognosy, Tishk International University, Erbil 44001, KRG, Iraq.ORCID 0000-0003-1760-6618
Dhanalekshmi Unnikrishnan MeenakshiCollege of Pharmacy, National University of Science and Technology, Muscat 130, Oman.ORCID 0000-0002-2689-4079
Rishabha MalviyaDepartment of Pharmacy, SMAS, Galgotias University, Gautam Buddh Nagar, Greater Noida 201310, India.
Mireia Mallandrich MiretDepartment of Pharmacy, Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0001-9316-8459
Ajay MendirattaDepartment of Pharmacy, SMAS, Galgotias University, Gautam Buddh Nagar, Greater Noida 201310, India.
Neeraj Kumar FuloriaFaculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia.
Gomal University · PKAIMST University · MYGalgotias University · INInternational Islamic University Malaysia · MYMahsa University · MYTishk International University · IQUniversitat de Barcelona · ESUniversity of Kuala Lumpur · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the present study was to develop emulsions encapsulated by chitosan on the outer surface of a nano droplet containing 5-fluorouracil (5-FU) as a model drug. The emulsions were characterized in terms of size, pH and viscosity and were evaluated for their physicochemical properties such as drug release and skin permeation in vitro. The emulsions containing tween 80 (T80), sodium lauryl sulfate, span 20, and a combination of polyethylene glycol (PEG) and T20 exhibited a release of 88%, 86%, 90% and 92%, respectively. Chitosan-modified emulsions considerably controlled the release of 5-FU compared to a 5-FU solution (

Indexed as

5-fluorouracilchitosanemulsionssurfactantstransdermal delivery

Identifiers

PMID34641162
PMCPMC8512026
OpenAlexW3203505311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.