Evidence map›Paper›PMID 34641097›Full record

ArticlePolymers2021

Preparation of Foam Dressings Based on Gelatin, Hyaluronic Acid, and Carboxymethyl Chitosan Containing Fibroblast Growth Factor-7 for Dermal Regeneration.

Longhao Jin, Sun-Jung Yoon, Dae Hoon Lee, Yun Chang Pyun, Woo Youp Kim, Ju Hwa Lee, Gilson Khang, Heung Jae Chun, Dae Hyeok Yang

Abstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. [Research advances of natural biomaterials in promoting wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Longhao JinDepartment of Orthopedic Surgery, Yanbian University Hospital, Yanji 133000, China.
Sun-Jung YoonDepartment of Orthopedic Surgery, Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju 54896, Korea.
Dae Hoon LeeDepartment of Bionanotechnology and Bioconvergence Engineering, Department of Polymer Nano Science and Technology, Jeonbuk National University, Jeonju 54896, Korea.ORCID 0000-0003-1139-1484
Yun Chang PyunDepartment of Bionanotechnology and Bioconvergence Engineering, Department of Polymer Nano Science and Technology, Jeonbuk National University, Jeonju 54896, Korea.
Woo Youp KimDepartment of Bionanotechnology and Bioconvergence Engineering, Department of Polymer Nano Science and Technology, Jeonbuk National University, Jeonju 54896, Korea.
Ju Hwa LeeDepartment of Bionanotechnology and Bioconvergence Engineering, Department of Polymer Nano Science and Technology, Jeonbuk National University, Jeonju 54896, Korea.
Gilson KhangDepartment of Bionanotechnology and Bioconvergence Engineering, Department of Polymer Nano Science and Technology, Jeonbuk National University, Jeonju 54896, Korea.ORCID 0000-0002-6452-5653
Heung Jae ChunDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0002-0446-9901
Dae Hyeok YangInstitute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0001-9853-8332

Funding

Jeonbuk National University-Industrial Cooperation No. 2101000448Ministry of Trade, Industry & Energy (MOTIE, Korea) 20003560 and 20004627
6 · The paper itself

Abstract

Wound recovery close to the function of the native skin is the goal of wound healing. In this study, we prepared foam dressings (FDs; 2-GHC-FD-1-9, 5-GHC-FD-1-9, and 10-GHC-FD-1-9) composed of various concentrations of gelatin, hyaluronic acid, and carboxymethyl chitosan, which are chemically interconnected through amide bond formation, for evaluating wound healing. Tensile and cell proliferation tests showed that 2-GHC-FD-1-9 are suitable for wound dressing. For further evaluation, three types of FDs, 2-GHC-FD-1, 2-GHC-FD-4, and 2-GHC-FD-8 were chosen. The results of animal intradermal reactivity, water vapor transmission rate, and absorption rate of the three FDs indicated that 2-GHC-FD-8 is the most appropriate scaffold for wound healing. For wound healing acceleration, various concentrations of fibroblast growth factor-7 (FGF-7) was soaked in 2-GHC-FD-8 (2-GHC-FD-8/F1-6) and evaluated by using scanning electron microscopy, cell proliferation, release behavior, and in vivo animal tests. The FDs showed interconnected porous structures, increased cell proliferation until 8.0 × 10

Indexed as

carboxymethyl chitosanfibroblast growth factor-7 (FGF-7)gelatinhyaluronic acidwound healing

Identifiers

PMID34641097
PMCPMC8513034

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.