Evidence map›Paper›PMID 34640575›Full record

ArticleJournal of clinical medicine2021

A Pilot Randomized Controlled Trial of Effect of Genioglossus Muscle Strengthening on Obstructive Sleep Apnea Outcomes.

Maryam Maghsoudipour, Brandon Nokes, Naa-Oye Bosompra, Rachel Jen, Yanru Li, Stacie Moore, Pamela N DeYoung, Janelle Fine, Bradley A Edwards, Dillon Gilbertson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Telemedicine-delivered myofunctional therapy remodels upper airway anatomy in obstructive sleep apnea: a prospective controlled study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maryam MaghsoudipourDepartment of Medicine, University of California, La Jolla, San Diego, CA 92161, USA.ORCID 0000-0002-3756-5705
Brandon NokesDepartment of Medicine, University of California, La Jolla, San Diego, CA 92161, USA.ORCID 0000-0003-3515-7545
Naa-Oye BosompraDepartment of Medicine, University of California, La Jolla, San Diego, CA 92161, USA.
Rachel JenDepartment of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Yanru LiDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Stacie MooreDepartment of Medicine, University of California, La Jolla, San Diego, CA 92161, USA.
Pamela N DeYoungDepartment of Medicine, University of California, La Jolla, San Diego, CA 92161, USA.
Janelle FineDepartment of Medicine, University of California, La Jolla, San Diego, CA 92161, USA.
Bradley A EdwardsDepartment of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.
Dillon GilbertsonDepartment of Medicine, University of California, La Jolla, San Diego, CA 92161, USA.
Robert OwensDepartment of Medicine, University of California, La Jolla, San Diego, CA 92161, USA.
Todd MorganDepartment of Dentistry, Scripps Encinitas Hospital, Encinitas, CA 92024, USA.
Atul MalhotraDepartment of Medicine, University of California, La Jolla, San Diego, CA 92161, USA.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Assessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611k
NHLBI NIH HHS K24 HL132105NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS T32 HL134632NIA NIH HHS R01 AG063925NIH HHS UL1TR001442
6 · The paper itself

Abstract

The genioglossus is a major upper airway dilator muscle. Our goal was to assess the efficacy of upper airway muscle training on Obstructive Sleep Apnea (OSA) as an adjunct treatment. Sixty-eight participants with OSA (AHI > 10/h) were recruited from our clinic. They fall into the following categories: (a) Treated with Automatic Positive Airway Pressure (APAP), (

Indexed as

adjunctive treatmentcontinuous positive airway pressuregenioglossus musclemandibular advancement splintobstructive sleep apnea

Identifiers

PMID34640575
PMCPMC8509668

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.