Evidence map›Paper›PMID 34640572›Full record

ArticleJournal of clinical medicine2021

Levels of Impulsivity, Hyperactivity, and Inattention and the Association with Mental Health and Substance Use Severity in Opioid-Dependent Patients Seeking Treatment with Extended-Release Naltrexone.

Ann Tarja Karlsson, John-Kåre Vederhus, Thomas Clausen, Bente Weimand, Kristin Klemmetsby Solli, Lars Tanum

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ann Tarja KarlssonAddiction Unit, Sørlandet Hospital HF, 4604 Kristiansand, Norway.
John-Kåre VederhusAddiction Unit, Sørlandet Hospital HF, 4604 Kristiansand, Norway.
Thomas ClausenAddiction Unit, Sørlandet Hospital HF, 4604 Kristiansand, Norway.
Bente WeimandMental Health Services, Akershus University Hospital, Lørenskog, 1478 Oslo, Norway.
Kristin Klemmetsby SolliNorwegian Centre for Addiction Research, University of Oslo, 0315 Oslo, Norway.
Lars TanumDepartment of R&D in Psychiatric Health Care, Akershus University Hospital, 1478 Oslo, Norway.
Sørlandet Sykehus · NOUniversity of Oslo · NOAkershus University Hospital · NOOsloMet – Oslo Metropolitan University · NO

Funding

South-Eastern Norway Regional Health Authority 2019105The Research Council of Norway 269864
6 · The paper itself

Abstract

The level of impulsivity, hyperactivity, and inattention (IHI) is higher among patients with substance use disorder (SUD) than in the general population. However, the prevalence of such symptoms in patients seeking treatment with an opioid antagonist, such as extended-release naltrexone (XR-NTX), is unknown. We screened 162 patients with opioid use disorder (OUD) seeking treatment with XR-NTX in Norway using the Adult ADHD Self-Report Scale (ASRS) to estimate the prevalence of IHI alongside an assessment of mental and physical health and substance use. Sixty-six patients scored above the clinical cut-off on the ASRS. Higher levels of IHI were significantly associated with a longer history of frequent amphetamine use, current alcohol use, and greater mental distress. Mental distress was the strongest factor associated with higher levels of IHI. The introduction of screening for IHI and mental distress in opioid maintenance treatment and XR-NTX would likely improve the quality of care and enable clinicians to tailor interventions to the needs of patients with high levels of IHI to prevent treatment discontinuation.

Indexed as

extended-release naltrexoneimpulsivitymental distressopioid dependence

Identifiers

PMID34640572
PMCPMC8509800
OpenAlexW3202050355

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.