Evidence map›Paper›PMID 34640552›Full record

ReviewJournal of clinical medicine2021

The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis.

Kumar Jayant, Isabella Reccia, Piotr J Bachul, Yaser Al-Salmay, Jordan S Pyda, Mauro Podda, Angelica Perez-Gutierrez, Frank J M F Dor, Yolanda Becker, Diego di Sabato and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Observational
  6. Reduction in the risk of progression of solid organ transplant recipients infected by SARS-CoV-2 treated with monoclonal antibodies.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
    Review
  7. Article
  8. Review
  9. COVID-19 and kidney transplantation: the impact of remdesivir on renal function and outcome - a retrospective cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Kumar JayantTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-0490-7323
Isabella RecciaDepartment of Surgery and Cancer, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
Piotr J BachulTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-7694-1793
Yaser Al-SalmayTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
Jordan S PydaDepartment of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-2833-3953
Mauro PoddaDepartment of Emergency Surgery, Azienda Ospedaliero-Universitaria Di Cagliari, University Hospital Policlinico Duilio Casula, 09124 Cagliari, Italy.ORCID 0000-0001-9941-0883
Angelica Perez-GutierrezTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
Frank J M F DorImperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
Yolanda BeckerTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
Diego di SabatoTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
John LaMattinaTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
Rolf BarthTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
John FungTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
Piotr WitkowskiTransplantation Institute, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
University of Chicago · USImperial College Healthcare NHS Trust · GBAzienda Ospedaliero-Universitaria Cagliari · ITBeth Israel Deaconess Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we performed a meta-analysis of published clinical outcomes of corona virus disease 2019 (COVID-19) in hospitalized kidney transplant recipients. A systematic database search was conducted between December 1, 2019 and April 20, 2020. We analyzed 48 studies comprising 3137 kidney transplant recipients with COVID-19. Fever (77%), cough (65%), dyspnea (48%), and gastrointestinal symptoms (28%) were predominant on hospital admission. The most common comorbidities were hypertension (83%), diabetes mellitus (34%), and cardiac disease (23%). The pooled prevalence of acute respiratory distress syndrome and acute kidney injury were 58% and 48%, respectively. Invasive ventilation and dialysis were required in 24% and 22% patients, respectively. In-hospital mortality rate was as high as 21%, and increased to over 50% for patients in intensive care unit (ICU) or requiring invasive ventilation. Risk of mortality in patients with acute respiratory distress syndrome (ARDS), on mechanical ventilation, and ICU admission was increased: OR = 19.59, OR = 3.80, and OR = 13.39, respectively. Mortality risk in the elderly was OR = 3.90; however, no such association was observed in terms of time since transplantation and gender. Fever, cough, dyspnea, and gastrointestinal symptoms were common on admission for COVID-19 in kidney transplant patients. Mortality was as high as 20% and increased to over 50% in patients in ICU and required invasive ventilation.

Indexed as

COVID-19kidney transplantationSARS-CoV-2

Identifiers

PMID34640552
PMCPMC8509345
OpenAlexW3202736658

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.