Evidence map›Paper›PMID 34640540›Full record

ArticleJournal of clinical medicine2021

Personalization of Treatment for Patients with Childhood-Abuse-Related Posttraumatic Stress Disorder.

Chris M Hoeboer, Danielle A C Oprel, Rianne A De Kleine, Brian Schwartz, Anne-Katharina Deisenhofer, Maartje Schoorl, Willem A J Van Der Does, Agnes van Minnen, Wolfgang Lutz

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Chris M HoeboerInstitute of Psychology, Leiden University, Wassenaarsweg 52, 2333 AK Leiden, The Netherlands.ORCID 0000-0002-5991-1963
Danielle A C OprelInstitute of Psychology, Leiden University, Wassenaarsweg 52, 2333 AK Leiden, The Netherlands.ORCID 0000-0002-0832-0581
Rianne A De KleineInstitute of Psychology, Leiden University, Wassenaarsweg 52, 2333 AK Leiden, The Netherlands.
Brian SchwartzDepartment of Psychology, University of Trier, 54296 Trier, Germany.ORCID 0000-0003-4695-4953
Anne-Katharina DeisenhoferDepartment of Psychology, University of Trier, 54296 Trier, Germany.
Maartje SchoorlInstitute of Psychology, Leiden University, Wassenaarsweg 52, 2333 AK Leiden, The Netherlands.
Willem A J Van Der DoesInstitute of Psychology, Leiden University, Wassenaarsweg 52, 2333 AK Leiden, The Netherlands.
Agnes van MinnenPSYTREC, Bilthoven, Professor Bronkhorstlaan 2, 3723 MB Bilthoven, The Netherlands.
Wolfgang LutzDepartment of Psychology, University of Trier, 54296 Trier, Germany.ORCID 0000-0002-5141-3847
Leiden University · NLUniversität Trier · DERadboud University Nijmegen · NL

Funding

Innovatiefonds Zorgverzekeraars 3.180ZonMw 843001705
6 · The paper itself

Abstract

backgroundDifferences in effectiveness among treatments for posttraumatic stress disorder (PTSD) are typically small. Given the variation between patients in treatment response, personalization offers a new way to improve treatment outcomes. The aim of this study was to identify predictors of psychotherapy outcome in PTSD and to combine these into a personalized advantage index (PAI).

methodsWe used data from a recent randomized controlled trial comparing prolonged exposure (PE;

resultsMore depressive symptoms, less social support, more axis-1 diagnoses, and higher severity of childhood sexual abuse were predictors of worse treatment outcomes in PE and iPE. More emotion regulation difficulties, lower general health status, and higher baseline PTSD symptoms were predictors of worse treatment outcomes in STAIR+PE. Randomization to optimal treatment based on these predictors resulted in more improvement than suboptimal treatment in clinician assessed (Cohens'

conclusionPersonalization based on PAI is a promising tool to improve therapy outcomes in patients with CA-PTSD. Further studies are needed to replicate findings in prospective studies.

Indexed as

personalized advantage indexposttraumatic stress disorderpredictors treatment outcomeprolonged exposure therapySTAIR+PE

Identifiers

PMID34640540
PMCPMC8509230
OpenAlexW3203610595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.