ArticleJournal of clinical medicine2021
Predictors of Effectiveness of Platelet-Rich Plasma Therapy for Knee Osteoarthritis: A Retrospective Cohort Study.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Effectiveness of combined regenerative medicine and exercise therapy for patients with knee osteoarthritis: a scoping review.Frontiers in rehabilitation sciences · 2025Pooled it
- Perihepatic dedifferentiated liposarcoma mimicking IgG4-related disease.Clinical journal of gastroenterology · 2026Article
- Artificial Intelligence-Guided Precision Orthobiologics in Musculoskeletal Conditions.Journal of orthopaedic case reports · 2026Review
- Effects of Platelet-Rich Plasma Injection in Knee Osteoarthritis Stages 1-4: A Retrospective Cohort Study.Cureus · 2026Article
- Superior clinical outcomes with combined intra-articular platelet-rich plasma and hyaluronic acid compared with hyaluronic acid alone in knee osteoarthritis: A prospective comparative study.Journal of experimental orthopaedics · 2026Article
- Association of Baseline Femoral Trochlear T2* Mapping with Clinical Response to Platelet-Rich Plasma in Patellofemoral Chondropathy: A Retrospective Exploratory Study.Journal of clinical medicine · 2026Article
- Monthly multiple injections of leukocyte-poor platelet-rich plasma (ACP®) for knee osteoarthritis: clinical effectiveness across KL grades, dose-response plateau at four, and 24-month durability.Regenerative therapy · 2026Article
- Machine learning predicts clinical response to platelet-rich plasma therapy in knee osteoarthritis.Frontiers in medicine · 2026Article
- The Effect of Exosome Size in Platelet-Rich Plasma on Outcomes in Patients Treated for Knee Osteoarthritis.Orthopaedic journal of sports medicine · 2025Article
- Development of Explainable Machine Learning Models to Predict Outcomes After Platelet-Rich Plasma Injections for Knee Osteoarthritis.Orthopaedic journal of sports medicine · 2025Article
- Optimal frequency of platelet-rich plasma injections for managing osteoarthritis: A longitudinal study.Regenerative therapy · 2025Article
- Re-Evaluating Platelet-Rich Plasma Dosing Strategies in Sports Medicine: The Role of the "10 Billion Platelet Dose" in Optimizing Therapeutic Outcomes-A Narrative Review.Journal of clinical medicine · 2025Review
- Use of platelet-rich plasma in rheumatic diseases.Rheumatology international · 2024Review
- The Effect of Platelet Dose on Outcomes after Platelet Rich Plasma Injections for Musculoskeletal Conditions: A Systematic Review and Meta-Analysis.Current reviews in musculoskeletal medicine · 2024Review
- Effects of platelet-rich plasma combined with exercise therapy for one year on knee osteoarthritis: retrospective cohort study.Journal of orthopaedic surgery and research · 2024Article
- The Outcomes at 3 Years in 82 Knees with Kellgren and Lawrence 2-3 Osteoarthritis Treated with an Autologous Protein Fluid Concentrate Produced with a Fluid Volume Reducer.Life (Basel, Switzerland) · 2024Article
- Platelet-Rich Plasma for Knee and Hip Osteoarthritis Pain: A Scoping Review.Current reviews in musculoskeletal medicine · 2024Article
- Factors affecting the therapeutic effects of multiple intra-articular injections of platelet-rich-plasma for knee osteoarthritis.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2024Article
- Minimally Invasive Therapies for Knee Osteoarthritis.Journal of personalized medicine · 2024Review
- Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
There has recently been growing interest worldwide in biological therapies such as platelet-rich plasma injection for the treatment of knee osteoarthritis. However, predicting the effectiveness of platelet-rich plasma therapy remains uncertain. Therefore, this retrospective cohort study was performed to assess a range of predictors for the effectiveness of platelet-rich plasma therapy in treating knee osteoarthritis. The study included 517 consecutive patients who underwent three injections of leucocyte-poor platelet-rich plasma therapy from 2016 to 2019 at a single institution. The treatment outcomes, including patient-oriented outcomes (visual analogue scale score and Knee Injury and Osteoarthritis Outcome Score), were analyzed and compared according to the severity of knee osteoarthritis based on Kellgren-Lawrence (KL) grading using standing plain radiographs. Fisher's exact test, univariate regression, and multivariate regression were used for data analysis. Patient-oriented outcomes were significantly improved 6 and 12 months after platelet-rich plasma therapy. The overall responder rate in patients who met the Outcome Measures in Rheumatology (OMERACT)-Osteoarthritis Research Society International (OARSI) responder criteria was 62.1%. The responder rate was significantly lower in patients with severe knee osteoarthritis (KL4, 50.9%) than in those with mild (KL2, 75.2%) and moderate (KL3, 66.5%) knee osteoarthritis. The multivariate logistic regression analysis revealed that deterioration of the knee osteoarthritis grade (increased KL grade) was a significant predictor of a worse clinical outcome (odds ratio, 0.58; 95% confidence interval, 0.45-0.75;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.