Evidence map›Paper›PMID 34640504›Full record

ReviewJournal of clinical medicine2021

Ankle Osteoarthritis Aetiology.

Mario Herrera-Pérez, David González-Martín, Mercedes Vallejo-Márquez, Alexandre L Godoy-Santos, Victor Valderrabano, Sergio Tejero

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. The sensory innervation pattern of the ankle: a systematic review.Surgical and radiologic anatomy : SRA · 2025
    Pooled it
  2. Review
  3. Article
  4. [Corrective osteotomy of the ankle joint].Orthopadie (Heidelberg, Germany) · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Synovial Dysregulation in Ankle Osteoarthritis: Molecular Insights and Pathogenetic Pathways.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  13. Review
  14. Task-Agnostic Exoskeleton Torque Assistance Reduces Ankle Osteoarthritis Pain: A Pilot Study.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  15. Article
  16. Article
  17. Osteoarthritis.Nature reviews. Disease primers · 2025
    Review
  18. Current concepts in ankle arthrodesis.Journal of clinical orthopaedics and trauma · 2024
    Article
  19. Article
  20. Increased subtalar rotational motion in patients with symptomatic ankle instability under load and stress conditions.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mario Herrera-PérezFoot and Ankle Unit, Orthopedic Surgery and Traumatology Service, Hospital Universitario de Canarias, Carretera de la Cuesta s/n, 38320 Santa Cruz de Tenerife, Spain.ORCID 0000-0001-6188-5269
David González-MartínFoot and Ankle Unit, Orthopedic Surgery and Traumatology Service, Hospital Universitario de Canarias, Carretera de la Cuesta s/n, 38320 Santa Cruz de Tenerife, Spain.ORCID 0000-0002-4891-515X
Mercedes Vallejo-MárquezMusculoskeletal Radiology Unit, Hospital Universitario Virgen del Rocío, Av. Manuel Siurot, s/n, 41013 Sevilla, Spain.
Alexandre L Godoy-SantosHospital Israelita Albert Einstein, Av. Albert Einstein, 627, Sao Paulo 05652-900, SP, Brazil.
Victor ValderrabanoOrthopaedic Department, Swiss Ortho Center, Schmerzklinik Basel, Hirschgässlein 15, 4051 Basel, Switzerland.
Sergio TejeroFoot and Ankle Unit, Orthopedic Surgery and Traumatology Service, Hospital Universitario Virgen del Rocío, Av. Manuel Siurot, s/n, 41013 Sevilla, Spain.
Hospital Universitario Virgen del Rocío · ESUniversidad de La Laguna · ESHospital Israelita Albert Einstein · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ankle osteoarthritis affects 1% of the population and, unlike gonarthrosis or coxarthrosis, is secondary to previous trauma in more than 75% of cases. Another peculiarity of this disease is that it affects a younger and active population, with socio-occupational implications. Mechanical factors, such as incongruity, instability, malalignment, and impacts, which increase stress on isolated areas of the ankle cartilage, have been clearly associated with the development of osteoarthritis. However, we cannot ignore the importance of pro-inflammatory mediators present from the moment of fracture as triggers of the cascade that eventually causes chondrocyte cell death, ultimately responsible for ankle osteoarthritis.

Indexed as

ankle cartilageankle fracturesankle osteoarthritisetiology

Identifiers

PMID34640504
PMCPMC8509242
OpenAlexW3203266113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.