ReviewJournal of clinical medicine2021
Cardioplegia between Evolution and Revolution: From Depolarized to Polarized Cardiac Arrest in Adult Cardiac Surgery.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07426237 (Effect of the Addition of Adenosine on Myocardial Protection During Cardiopulmonary Bypass), which is not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of the Addition of Adenosine on Myocardial Protection During Cardiopulmonary Bypass: A Double-Blind Randomized Clinical Trial
Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Comparing del Nido and St. Thomas II cardioplegia in a rat ischemia-reperfusion model: Histopathology, mitochondria, and TEM analysis.Biomolecules & biomedicine · 2025Article
- Superiority of antegrade cardioplegia over continuous hypothermic retrograde cardioplegia in myocardial protection during isolated aortic valve replacement.JTCVS techniques · 2025Article
- Diabetes Mellitus and Cardiopulmonary Bypass (CPB): Pathophysiological Mechanisms Related to Inflammation and Cardiovascular Disease.Current issues in molecular biology · 2025Review
- Beyond Uncertainty: Establishing the Oda Strategy for the Treatment of Acute Aortic Dissection.Journal of clinical medicine · 2025Review
- The novel St Thomas' Hospital polarizing blood cardioplegia: results in hearts with reduced ejection fraction.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Selective Vein Graft Cold Cardioplegia and Warm Reperfusion to Enhance Early Recovery in Patients with Left Ventricle Depression Undergoing Coronary Artery Surgery.Journal of cardiovascular development and disease · 2025Article
- Comparison of Del Nido and histidine-tryptophan-ketoglutarate cardioplegia solutions: an animal study with prolonged ischaemia.Frontiers in cardiovascular medicine · 2024Article
- Review
- Cardioplegia in Open Heart Surgery: Age Matters.Journal of clinical medicine · 2023Review
- Hyperkalemic or Low Potassium Cardioplegia Protects against Reduction of Energy Metabolism by Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Article
- Theoretical and Practical Aspects in the Use of Bretschneider Cardioplegia.Journal of cardiovascular development and disease · 2022Review
- Temperature-Related Effects of Myocardial Protection Strategies in Swine Hearts after Prolonged Warm Ischemia.Antioxidants (Basel, Switzerland) · 2022Article
- St. Thomas Modified Cardioplegia Effects on Myoblasts' Viability and Morphology.Medicina (Kaunas, Lithuania) · 2022Article
- The Role of Purinergic Signaling in Heart Transplantation.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite current advances in perioperative care, intraoperative myocardial protection during cardiac surgery has not kept the same pace. High potassium cardioplegic solutions were introduced in the 1950s, and in the early 1960s they were soon recognized as harmful. Since that time, surgeons have minimized many of the adverse effects by lowering the temperature of the heart, lowering K
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.