Evidence map›Paper›PMID 34640496›Full record

ArticleJournal of clinical medicine2021

Intra-Anal Imiquimod Cream against Human Papillomavirus Infection in Men Who Have Sex with Men Living with HIV: A Single-Arm, Open-Label Pilot Study.

Duygu Durukan, Tiffany R Phillips, Gerald L Murray, Jason J Ong, Andrew E Grulich, I Mary Poynten, Fengyi Jin, Catriona S Bradshaw, Ivette Aguirre, Julie Silvers and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Evidence for Anal Dysplasia Treatment.Clinics in colon and rectal surgery · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Duygu DurukanCentral Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Tiffany R PhillipsCentral Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Gerald L MurrayMurdoch Children's Research Institute, Parkville, VIC 3052, Australia.
Jason J OngCentral Clinical School, Monash University, Melbourne, VIC 3004, Australia.ORCID 0000-0001-5784-7403
Andrew E GrulichThe Kirby Institute, UNSW Sydney, Sydney, NSW 2052, Australia.
I Mary PoyntenThe Kirby Institute, UNSW Sydney, Sydney, NSW 2052, Australia.
Fengyi JinThe Kirby Institute, UNSW Sydney, Sydney, NSW 2052, Australia.
Catriona S BradshawCentral Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Ivette AguirreMelbourne Sexual Health Centre, Alfred Health, Carlton, VIC 3053, Australia.
Julie SilversMelbourne Sexual Health Centre, Alfred Health, Carlton, VIC 3053, Australia.
Helen KentMelbourne Sexual Health Centre, Alfred Health, Carlton, VIC 3053, Australia.
Steph AtchisonMurdoch Children's Research Institute, Parkville, VIC 3052, Australia.
Prisha BalgovindMurdoch Children's Research Institute, Parkville, VIC 3052, Australia.
Alyssa CornallMurdoch Children's Research Institute, Parkville, VIC 3052, Australia.
Marcus Y ChenCentral Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Christopher K FairleyCentral Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Eric P F ChowCentral Clinical School, Monash University, Melbourne, VIC 3004, Australia.ORCID 0000-0003-1766-0657
Melbourne Sexual Health Centre · AURoyal Women's Hospital · AUUNSW Sydney · AUThe University of Melbourne · AU

Funding

National Health and Medical Research Council GNT1172873National Health and Medical Research Council GNT1172900National Health and Medical Research Council GNT1173361National Health and Medical Research Council GNT568971
6 · The paper itself

Abstract

Men who have sex with men (MSM) living with HIV have a high prevalence and incidence of anal high-risk human papillomavirus (hrHPV) and anal cancer. We conducted an open-label, single-arm pilot study to examine the tolerability of imiquimod cream among MSM aged ≥18 years, living with HIV, who tested positive for anal hrHPV at Melbourne Sexual Health Centre between April 2018 and June 2020. We instructed men to apply 6.25 mg imiquimod intra-anally and peri-anally 3 doses per week for 16 weeks (period 1) and then one dose per week for a further 48 weeks (period 2). Twenty-seven MSM enrolled in period 1 and 24 (86%) applied at least 50% of doses. All men reported adverse events (AEs), including 39.5% grade 1, 39.5% grade 2, and 21% grade 3 AEs on at least one occasion. Eighteen MSM (67%) temporarily stopped using imiquimod during period 1, most commonly due to local AEs (

Indexed as

anal canceranusHPVinterventionmenprevention

Identifiers

PMID34640496
PMCPMC8509144
OpenAlexW3204922496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.