Evidence map›Paper›PMID 34640482›Full record

ReviewJournal of clinical medicine2021

Association of Nonalcoholic Fatty Liver Disease (NAFLD) with Peripheral Diabetic Polyneuropathy: A Systematic Review and Meta-Analysis.

Carla Greco, Fabio Nascimbeni, Francesca Carubbi, Pietro Andreone, Manuela Simoni, Daniele Santi

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Correlation Between Fibrinogen/Albumin and Diabetic Peripheral Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carla GrecoUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 42121 Modena, Italy.ORCID 0000-0002-9675-3677
Fabio NascimbeniDivision of Internal Medicine and Metabolism, Department of Internal Medicine, Azienda Ospedaliero-Universitaria of Modena, Ospedale Civile di Baggiovara, 41125 Modena, Italy.ORCID 0000-0002-1051-1272
Francesca CarubbiDivision of Internal Medicine and Metabolism, Department of Internal Medicine, Azienda Ospedaliero-Universitaria of Modena, Ospedale Civile di Baggiovara, 41125 Modena, Italy.ORCID 0000-0001-7504-6407
Pietro AndreoneDivision of Internal Medicine and Metabolism, Department of Internal Medicine, Azienda Ospedaliero-Universitaria of Modena, Ospedale Civile di Baggiovara, 41125 Modena, Italy.ORCID 0000-0002-4794-9809
Manuela SimoniUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 42121 Modena, Italy.ORCID 0000-0002-2133-4304
Daniele SantiUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 42121 Modena, Italy.ORCID 0000-0001-6607-7105

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe relationship between nonalcoholic fatty liver disease (NAFLD) and diabetic polyneuropathy (DPN) has been demonstrated in many studies, although results were conflicting. This meta-analysis aims to summarize available data and to estimate the DPN risk among NAFLD patients. MATERIALS AND

methodsWe performed a comprehensive literature review until 4 June 2021. Clinical trials analyzing the association between NAFLD and DPN were included.

resultsThirteen studies (9614 participants) were included. DPN prevalence was significantly higher in patients with NALFD, compared to patients without NAFLD (OR (95%CI) 2.48 (1.42-4.34),

conclusionDespite a high heterogeneity among studies, a significantly increased DPN prevalence among type 2 diabetes subjects with NAFLD was observed. This result was not found in type 1 diabetes, probably due to the longer duration of disease. Physicians should pay more attention to the early detection of DPN, especially in patients with NAFLD.

Indexed as

diabetes mellitusNAFLDperipheral polyneuropathy

Identifiers

PMID34640482
PMCPMC8509344

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.