Evidence map›Paper›PMID 34640474›Full record

ReviewJournal of clinical medicine2021

Effects of Probiotics, Prebiotics, and Synbiotics on Uremic Toxins, Inflammation, and Oxidative Stress in Hemodialysis Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Thi Thuy Uyen Nguyen, Hyeong Wan Kim, Won Kim

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06891105 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Probiotic and Synbiotic Administration on the Nutritional Status of Hemodialysis Patients. a Randomized Controlled Trial

TypeinterventionalSponsorMansoura UniversityRan2025 to 2025Enrolled60ConditionsHemodialysis, Probiotics, Synbiotics, Nutritional StatusArmsLactogemikan (Probiotic Supplement), Lactogemikan + Prebiotic Fiber (Synbiotic Supplement)
NCT07531186 nacompletednot on this mapstarted 2025, after this paper: background citation

Effects of Probiotic and Synbiotic Administration on the Clinical and Biochemical Characteristics of Hemodialysis Patients: A Randomized Controlled Trial

TypeinterventionalSponsorMansoura UniversityRan2025 to 2025Enrolled60ConditionsEnd Stage Renal Disease (ESRD), Kidney Failure, Chronic, HemodialysisArmsNatural Probiotic Supplement, Natural Synbiotic Supplement (Probiotic + Prebiotic Oat Fiber)
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Thi Thuy Uyen NguyenDepartment of Histology, Embryology, Pathology and Forensic Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue 52000, Vietnam.ORCID 0000-0003-2940-6760
Hyeong Wan KimDepartment of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54896, Korea.ORCID 0000-0001-5909-1662
Won KimDepartment of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54896, Korea.ORCID 0000-0003-1068-1455
Hue University · VNJeonbuk National University · KRJeonbuk National University Hospital · KR

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF-2019R1A2C1090358)Biomedical Research Institute, Jeonbuk National University Hospital (K.W.)
6 · The paper itself

Abstract

The dysbiosis of gut microbiota may cause many complications in patients with end-stage renal disease, which may be alleviated by probiotic, prebiotic, and synbiotic supplementation. The aim of this systematic review and meta-analysis was to assess the effects of these supplementations on circulatory uremic toxins, biomarkers of inflammation, and oxidative stress in hemodialysis patients. We searched the EMBASE, MEDLINE, Web of Science, and Cochrane Library databases until 8 August 2021. Randomized controlled trials evaluating adult patients receiving hemodialysis were included. The pooled results from 23 studies with 931 hemodialysis patients indicated that interventions significantly decreased the circulating levels of p-cresyl sulfate (standardized mean difference (SMD): 0.38; 95% CI: -0.61, -0.15;

Indexed as

chronic kidney diseasehemodialysisprebioticprobioticsynbiotic

Identifiers

PMID34640474
PMCPMC8509328
OpenAlexW3202149489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.