ArticleJournal of clinical medicine2021
Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu.
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Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Systematic Review and Meta-Analysis: Association between Preoperative Ustekinumab and Surgical Complications in Crohn's Disease Patients.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2023Pooled it
- Management of Crohn's Disease in Adult Patients: A Contemporary Surgical Perspective.Biomedicines · 2026Review
- Biologics Before Surgery Are Not Associated With Complications After Surgery for IBD: A National Surgery Quality Improvement Program IBD Collaborative Causal Inference Analysis.Diseases of the colon and rectum · 2026Article
- Cost-Effectiveness Analysis of Etrasimod Compared With Biologic Therapies for the Treatment of Patients with Moderately-to-Severely Active Ulcerative Colitis in Spain.PharmacoEconomics - open · 2026Article
- Common Mistakes in Managing Patients with Inflammatory Bowel Disease.Journal of clinical medicine · 2024Review
- Peri-Operative Optimization of Patients with Crohn's Disease.Current gastroenterology reports · 2024Review
- The Effect of Anti-Tumor Necrosis Factor-Alpha Therapy within 12 Weeks Prior to Surgery on Postoperative Complications in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Association between preoperative biologic use and surgical morbidity in patients with Crohn's disease.International journal of colorectal disease · 2022Article
- Special Issue "Clinical Advances in Chronic Intestinal Diseases Treatment".Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
65 authors at 20 institutions in 1 country.
María José GarcíaGastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, Spain.ORCID 0000-0002-6517-7005
Montserrat RiveroGastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, Spain.ORCID 0000-0002-5834-1559
José Miranda-BautistaGastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, 28009 Madrid, Spain.
Iria Bastón-ReyGastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, Spain.
Francisco MesoneroGastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.ORCID 0000-0002-7864-8187
Eduardo Leo-CarnereroGastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.ORCID 0000-0002-1267-5211
Diego Casas-DezaGastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, Spain.ORCID 0000-0001-6883-8940
Carmen Cagigas FernándezColorectal Unit, Department of General and Digestive Surgery, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain.
Albert Martin-CardonaGastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08221 Terrassa, Spain.ORCID 0000-0002-7090-0106
Ismael El HajraGastroenterology Department, Hospital Universitario Puerta de Hierro, 28220 Majadahonda, Spain.
Nerea Hernández-AretxabaletaGastroenterology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain.
Isabel Pérez-MartínezDepartment of Gastroenterology, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain.
Esteban Fuentes-ValenzuelaGastroenterology Department, Hospital Universitario Río Hortega, 47012 Valladolid, Spain.
Nuria JiménezGastroenterology Department, Hospital General Universitario de Elche, 03203 Alicante, Spain.
Cristina Rubín de CélixGastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain.ORCID 0000-0003-3611-8994
Ana GutiérrezGastroenterology Department, Hospital General de Alicante, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), 03010 Alicante, Spain.ORCID 0000-0002-5460-4139
Cristina Suárez FerrerGastroenterology Department, Hospital Universitario La Paz, 28046 Madrid, Spain.
José María HuguetGastroenterology Department, Hospital General Universitario de Valencia, 46014 Valencia, Spain.
Agnes Fernández-ClotetGastroenterology Department, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0001-7513-0764
María González-VivóGastroenterology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0001-5857-3766
Blanca Del ValGastroenterology Department, Hospital Rafael Méndez, 30817 Lorca, Spain.
Jesús Castro-PoceiroGastroenterology Department, Hospital Sant Joan Despí-Moisès Broggi, 08970 Barcelona, Spain.
Luigi MelcarneGastroenterology Department, Hospital Universitari Parc Taulí, Sabadell, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08208 Barcelona, Spain.ORCID 0000-0002-9718-9692
Carmen DueñasGastroenterology Department, Hospital Universitario de Cáceres, 10003 Cáceres, Spain.
Marta IzquierdoGastroenterology Department, Hospital Universitario de Cabueñes, 33203 Gijón, Spain.
David MonfortGastroenterology Department, Consorcio Sanitario de Terrasa, 08227 Barcelona, Spain.
Abdel BouhmidiGastroenterology Department, Hospital de Santa Bárbara, 13500 Puertollano, Spain.
Patricia Ramírez De la PiscinaGastroenterology Department, Hospital Universitario Vitoria-Gastéiz, 01002 Vitoria, Spain.
Eva RomeroGastroenterology Department, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain.ORCID 0000-0003-2563-8177
Gema MolinaGastroenterology Department, Hospital Arquitecto Marcide, 15405 Ferrol, Spain.
Jaime ZorrillaDepartment of Colorectal and Gastrointestinal Surgery, Hospital Universitario Gregorio Marañón, 28009 Madrid, Spain.
Cristina Calvino-SuárezGastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, Spain.
Eugenia SánchezGastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.ORCID 0000-0001-9771-7865
Andrea NuñezGastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.
Olivia SierraGastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, Spain.
Beatriz CastroGastroenterology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 37008 Santander, Spain.
Yamile ZabanaGastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08221 Terrassa, Spain.ORCID 0000-0003-4023-8868
Irene González-PartidaGastroenterology Department, Hospital Universitario Puerta de Hierro, 28220 Majadahonda, Spain.
Saioa De la MazaGastroenterology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain.
Andrés CastañoDepartment of Gastroenterology, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain.ORCID 0000-0002-7921-9026
Rodrigo Nájera-MuñozGastroenterology Department, Hospital Universitario Río Hortega, 47012 Valladolid, Spain.
Luis Sánchez-GuillénDepartment of Colorectal and Gastrointestinal Surgery, Hospital General Universitario de Elche, 03203 Alicante, Spain.ORCID 0000-0003-0623-9074
Micaela Riat CastroGastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain.
José Luis RuedaGastroenterology Department, Hospital Universitario La Paz, 28046 Madrid, Spain.
José Manuel BenítezGastroenterology Department, Hospital Reina Sofía, IMIBIC, 14004 Córdoba, Spain.
Pedro Delgado-GuillenaGastroenterology Department, Hospital General de Granollers, 08042 Granollers, Spain.
Carlos TardilloGastroenterology Department, Hospital Nuestra Señora de la Candelaria, 38010 Tenerife, Spain.
Elena PeñaGastroenterology Department, Hospital Royo Villanova, 50007 Zaragoza, Spain.
Santiago Frago-LarramonaGastroenterology Department, Complejo Hospitalario de Soria, 42005 Soria, Spain.
María Carmen Rodríguez-GrauGastroenterology Department, Hospital Universitario de Henares, 28002 Coslada, Spain.
Rocío PlazaGastroenterology Department, Hospital Universitario Infanta Leonor, Vallecas, 28031 Madrid, Spain.
Pablo Pérez-GalindoGastroenterology Department, Complejo Hospitalario Universitario de Pontevedra, 36071 Pontevedra, Spain.
Jesús Martínez-CadillaGastroenterology Department, Hospital Álvaro Cunqueiro de Vigo, 36312 Vigo, Spain.
Luis MenchénGastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, 28009 Madrid, Spain.
Manuel Barreiro-De AcostaGastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, Spain.ORCID 0000-0001-5915-1477
Rubén Sánchez-AldehueloGastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.ORCID 0000-0002-7597-5596
María Dolores De la CruzGastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.
Luis Javier LamuelaGastroenterology Department, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IISA), 50009 Zaragoza, Spain.
Ignacio MarínGastroenterology Department, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), and Departamento de Medicina, Universidad Complutense, 28009 Madrid, Spain.
Laura Nieto-GarcíaGastroenterology Department, Hospital Universitario Clínico de Santiago, 15706 Santiago de Compostela, Spain.
Antonio López-San RománGastroenterology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
José Manuel HerreraGastroenterology Department, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.
María ChaparroGastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain.ORCID 0000-0002-9275-4242
Javier P GisbertGastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain.ORCID 0000-0003-2090-3445
On Behalf Of The Young Group Of Geteccu
Complejo Hospitalario Universitario de Santiago · ESHospital General Universitario Gregorio Marañón · ESHospital Universitario de La Princesa · ESHospital Universitario Ramón y Cajal · ESHospital Universitario Virgen del Rocío · ESHospital Universitario Miguel Servet · ESUniversidad de Cantabria · ESCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESHospital de Basurto · ESHospital General Universitario de Elche · ESHospital Universitario La Paz · ESHospital Universitario Puerta de Hierro Majadahonda · ESHospital Universitario Río Hortega · ESInstituto de Investigación Sanitaria del Principado de Asturias · ESUniversity Hospital Mútua de Terrassa · ESComplejo Hospitalario de Cáceres · ESComplejo Hospitalario de Pontevedra · ESComplejo Hospitalario Universitario de Ferrol · ESConsorci Sanitari de Terrassa · ESHospital Clínic de Barcelona · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab.
aimsTo evaluate the impact of biologics on the risk of PC.
methodsA retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered "exposed". The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis.
resultsA total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2-2.0), urgent surgery (OR: 1.6; 95% CI: 1.2-2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1-1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3-2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97-1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03-2.27).
conclusionsPreoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections.
Indexed as
anti-TNFCrohn’s diseaseinflammatory bowel diseasepostoperative complicationspreoperative therapysurgeryulcerative colitisustekinumabvedolizumab
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