Evidence map›Paper›PMID 34640369›Full record

ArticleJournal of clinical medicine2021

Impact of Epithelial-Mesenchymal Immunophenotype on Local Aggressiveness in Papillary Thyroid Carcinoma Invading the Airway.

Martina Mandarano, Marco Andolfi, Renato Colella, Massimo Monacelli, Andrea Polistena, Sonia Moretti, Guido Bellezza, Efisio Puxeddu, Alessandro Sanguinetti, Angelo Sidoni and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Reprogramming of fatty acid metabolism in thyroid cancer: Potential targets and mechanisms.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Martina MandaranoSection of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.ORCID 0000-0001-5019-4825
Marco AndolfiThoracic Surgery Unit, AOU Ospedali Riuniti di Ancona, 60126 Ancona, Italy.ORCID 0000-0002-0399-7374
Renato ColellaSection of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.
Massimo MonacelliThoracic Surgery Unit, University of Perugia Medical School, 06132 Perugia, Italy.
Andrea PolistenaDepartment of Surgery "Pietro Valdoni", Policlinico Umberto I, University of Rome "Sapienza", 00161 Rome, Italy.ORCID 0000-0002-1319-1147
Sonia MorettiInternal Medicine and Endocrine and Metabolic Sciences Unit, University of Perugia Medical School, 06132 Perugia, Italy.
Guido BellezzaSection of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.ORCID 0000-0002-6337-1701
Efisio PuxedduInternal Medicine and Endocrine and Metabolic Sciences Unit, University of Perugia Medical School, 06132 Perugia, Italy.
Alessandro SanguinettiGeneral and Specialized Surgery, University of Perugia Medical School, Santa Maria Hospital, 05100 Terni, Italy.
Angelo SidoniSection of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.
Nicola AveniaGeneral and Specialized Surgery, University of Perugia Medical School, Santa Maria Hospital, 05100 Terni, Italy.
Francesco PumaThoracic Surgery Unit, University of Perugia Medical School, 06132 Perugia, Italy.
Jacopo VannucciThoracic Surgery and Lung Transplantation Unit, Policlinico Umberto I, University of Rome "Sapienza", 00161 Rome, Italy.
University of Perugia · ITPoliclinico Umberto I · ITOspedali Riuniti di Ancona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary thyroid tumours show different levels of aggressiveness, from indolent to rapidly growing infiltrating malignancies. The most effective therapeutic option is surgery when radical resection is feasible. Biomarkers of aggressiveness may help in scheduling extended resections such as airway infiltration, avoiding a non-radical approach. The aim of the study is to evaluate the prognostic role of E-cadherin, N-cadherin, Aryl hydrocarbon receptor (AhR), and CD147 in different biological behaviours. Fifty-five samples from three groups of thyroid carcinomas were stained: papillary thyroid carcinomas (PTCs) infiltrating the airway (PTC-A), papillary intra-thyroid carcinomas (PTC-B) and poorly differentiated or anaplastic thyroid carcinomas (PDTC/ATC). High expressions of N-cadherin and AhR were associated with higher locoregional tumour aggressiveness (

Indexed as

airwaybiomarkersendocrine tumoursimmunohistochemistryneckpapillary thyroid carcinomapoorly differentiated thyroid carcinomathyroid cancertrachea

Identifiers

PMID34640369
PMCPMC8509765
OpenAlexW3202311343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.