ArticleJournal of clinical medicine2021
Severe Fatigue and Memory Impairment Are Associated with Lower Serum Level of Anti-SARS-CoV-2 Antibodies in Patients with Post-COVID Symptoms.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Prevalence of severe fatigue after SARS-CoV-2 infection in Norway: a prospective 2-year follow-up study.BMJ open · 2026Article
- A multinational cross-sectional study on the prevalence and predictors of long COVID across 33 countries.Scientific reports · 2025Article
- Novel biomarkers of mitochondrial dysfunction in Long COVID patients.GeroScience · 2025Article
- Defining and measuring long COVID fatigue: a scoping review.BMJ open · 2024Article
- The multifaceted effects of migraine on Syrian society: insights from a multicenter cross-sectional study.BMC neurology · 2024Article
- Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches.GeroScience · 2024Review
- Long Neuro-COVID-19: Current Mechanistic Views and Therapeutic Perspectives.Biomolecules · 2024Review
- Changes in Working Situations of Employed Long COVID Patients: Retrospective Study in Japanese Outpatient Clinic.Journal of clinical medicine · 2024Article
- Impact of Circulating Anti-Spike Protein Antibody Levels on Multi-Organ Long COVID Symptoms.Vaccines · 2024Article
- Clinical and serological predictors of post COVID-19 condition-findings from a Canadian prospective cohort study.Frontiers in public health · 2024Article
- The Association between Dysnatraemia during Hospitalisation and Post-COVID-19 Mental Fatigue.Journal of clinical medicine · 2023Article
- Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers.International journal of molecular sciences · 2023Article
- Cystatin-c May Indicate Subclinical Renal Involvement, While Orosomucoid Is Associated with Fatigue in Patients with Long-COVID Syndrome.Journal of personalized medicine · 2023Article
- Long COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches.Journal of personalized medicine · 2023Review
- Neuropsychiatric aspects of long COVID: A comprehensive review.Psychiatry and clinical neurosciences · 2023Review
- Association between serologically confirmed COVID-19 infection and cognitive functioning in community dwelling older adults.Frontiers in neurology · 2023Article
- Post-viral fatigue in COVID-19: A review of symptom assessment methods, mental, cognitive, and physical impairment.Neuroscience and biobehavioral reviews · 2022Review
- Exploring the recovery curve for long-term post-COVID dyspnea and fatigue.European journal of internal medicine · 2022Article
- Serum Level of Anti-Nucleocapsid, but Not Anti-Spike Antibody, Is Associated with Improvement of Long COVID Symptoms.Vaccines · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-COVID manifestation is defined as persistent symptoms or long-term complications beyond 4 weeks from disease onset. Fatigue and memory impairment are common post-COVID symptoms. We aimed to explore associations between the timeline and severity of post-COVID fatigue and anti-SARS-CoV-2 antibodies.
methodsFatigue and memory impairment were assessed in a total of 101 post-COVID subjects using the Chalder fatigue scale (CFQ-11) and a visual analogue scale. Using the bimodal scoring system generated from CFQ-11, a score ≥4 was defined as severe fatigue. Serum anti-SARS-CoV-2 spike (anti-S-Ig) and nucleocapsid (anti-NC-Ig) antibodies were examined at two time points: 4-12 weeks after onset of symptoms, and beyond 12 weeks.
resultsThe serum level of anti-S-Ig was significantly higher in patients with non-severe fatigue compared to those with severe fatigue at 4-12 weeks (
conclusionThe systemic immune response reflected by antibodies to SARS-CoV-2 is strongly correlated with the severity of post-COVID fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.