ArticleJournal of clinical medicine2021
Coronary Microvascular Dysfunction in Takotsubo Syndrome Assessed by Angiography-Derived Index of Microcirculatory Resistance: A Pressure-Wire-Free Tool.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Role of sex on the efficacy of pharmacological and non-pharmacological treatment of heart failure with reduced ejection fraction: A systematic review.Frontiers in cardiovascular medicine · 2022Pooled it
- Coronary Microvascular Dysfunction in Stress Cardiomyopathy: At the Heart of the Problem.Life (Basel, Switzerland) · 2026Review
- Cardiomyopathies of endocrine origin: A state-of-the-art review.World journal of cardiology · 2025Review
- Coronary microvascular dysfunction is a hallmark of all subtypes of MINOCA.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Coronary microvascular dysfunction in Takotsubo syndrome: an analysis using angiography-derived index of microcirculatory resistance.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Effects of cardiovascular risk factors and pre-existing diseases on the short-term outcome of Takotsubo syndrome.Wiener klinische Wochenschrift · 2024Article
- Impact of Coronary Microvascular Dysfunction in Takotsubo Syndrome: Cause, Consequence or Both?Reviews in cardiovascular medicine · 2024Review
- An Extensive Review on Imaging Diagnosis Methods in Takotsubo Syndrome.Reviews in cardiovascular medicine · 2023Review
- Review
- Coronary microvascular dysfunction in Takotsubo syndrome and associations with left ventricular function.ESC heart failure · 2023Article
- Angiography-derived index of microvascular resistance in takotsubo syndrome.The international journal of cardiovascular imaging · 2023Article
- Prognostic value of coronary microvascular dysfunction assessed by coronary angiography-derived index of microcirculatory resistance in diabetic patients with chronic coronary syndrome.Cardiovascular diabetology · 2022Article
- Takotsubo Syndrome: From Bench to Bedside and Bedside to Bench.Journal of clinical medicine · 2022Article
- Plasma brain natriuretic peptide, platelet parameters, and cardiopulmonary function in chronic obstructive pulmonary disease.World journal of clinical cases · 2021Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary microvascular dysfunction (CMD) has been proposed as a key mechanism in Takotsubo syndrome (TTS). The non-hyperaemic angiography-derived index of microcirculatory resistance (NH-IMRangio) has been validated as a pressure-wire-free tool for the assessment of coronary microvasculature. We aimed to study the presence of CMD in TTS patients and its association with levels of cardiac biomarkers and systolic dysfunction patterns.
methodsWe recruited 181 consecutive patients admitted for TTS who underwent cardiac angiography at a tertiary center from January 2014 to January 2021. CMD was defined as an NH-IMRangio ≥ 25. Plasma levels of NT-proBNP, high-sensitive cardiac troponin T (hs-cTnT) and the left ventricular ejection fraction (LVEF) by echocardiography were measured at admission.
resultsMean age was 75.3 years, 83% were women and median LVEF was 45%. All patients presented CMD (NH-IMRangio ≥ 25) in at least one epicardial coronary artery. The left anterior descending artery (LAD) showed higher median NH-IMRangio values than left circumflex (LCx) and right coronary arteries (RCA) (44.6 vs. 31.3 vs. 36.1, respectively;
conclusionsCMD is highly prevalent in patients admitted for TTS and is associated with both a higher degree of systolic dysfunction and higher BNP levels, but not troponin.
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