Evidence map›Paper›PMID 34640345›Full record

ArticleJournal of clinical medicine2021

Comparative Outcomes of Budesonide MMX versus Prednisolone for Ulcerative Colitis: Results from a British Retrospective Multi-Centre Real-World Study.

Konstantina Rosiou, Elaine Ong Ming San, Aditi Kumar, Kim Esquivel, Saima Almas, Daniel Stokes, Tze Ng, Nishani Jayasooriya, Ian Ranasinghe, Richard Pollok and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Saudi consensus guidance for the diagnosis and management of inflammatory bowel disease in children and adolescents.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025
    Guideline
  2. Article
  3. Article
  4. The safe use of inflammatory bowel disease therapies during the COVID-19 pandemic.Current research in pharmacology and drug discovery · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Konstantina RosiouLeeds Gastroenterology Institute, Leeds Teaching Hospitals, Leeds LS9 7TF, UK.
Elaine Ong Ming SanLeeds Gastroenterology Institute, Leeds Teaching Hospitals, Leeds LS9 7TF, UK.
Aditi KumarDepartment of Gastroenterology, Royal Wolverhampton Hospital, Wolverhampton WV10 0QP, UK.ORCID 0000-0003-1026-3173
Kim EsquivelDepartment of Gastroenterology, Royal Wolverhampton Hospital, Wolverhampton WV10 0QP, UK.
Saima AlmasDepartment of Gastroenterology, Royal Wolverhampton Hospital, Wolverhampton WV10 0QP, UK.
Daniel StokesDepartment of Gastroenterology, Royal Wolverhampton Hospital, Wolverhampton WV10 0QP, UK.
Tze NgDepartment of Gastroenterology, St Georges Hospital, London SW17 0QT, UK.
Nishani JayasooriyaDepartment of Gastroenterology, St Georges Hospital, London SW17 0QT, UK.
Ian RanasingheDepartment of Gastroenterology, St Georges Hospital, London SW17 0QT, UK.
Richard PollokDepartment of Gastroenterology, St Georges Hospital, London SW17 0QT, UK.
Matthew BrookesDepartment of Gastroenterology, Royal Wolverhampton Hospital, Wolverhampton WV10 0QP, UK.ORCID 0000-0002-8782-0292
Christian P SelingerLeeds Gastroenterology Institute, Leeds Teaching Hospitals, Leeds LS9 7TF, UK.ORCID 0000-0003-2022-5859
St George's Hospital · GBWolverhampton Hospital · GBLeeds Teaching Hospitals NHS Trust · GBUniversity of Wolverhampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the COVID-19 pandemic many IBD units chose Budesonide MMX (Cortiment) as the first-line treatment for flares of ulcerative colitis (UC) in outpatients for its favourable side effect profile. This retrospective study of all UC patients treated with oral steroids between 1 March 2019-30 June 2019 and 1 March 2020-30 June 2020 aimed to compare Cortiment with Prednisolone in routine clinical practice. Outcomes included the need for hospitalisation for acute severe ulcerative colitis, symptoms at four weeks and end of treatment, and the need for rescue Prednisolone. The 2019 and 2020 cohorts did not differ at the baseline. Cortiment prescriptions rose from 24.5% in 2019 to 70.1% in 2020 (

Indexed as

Budesonide MMXCortimentCOVID-19inflammatory bowel diseaseprednisoloneulcerative colitis

Identifiers

PMID34640345
PMCPMC8509767
OpenAlexW3200663032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.