Evidence map›Paper›PMID 34640121›Full record

ArticleMaterials (Basel, Switzerland)2021

The Synthesis and Evaluation of Aminocoumarin Peptidomimetics as Cytotoxic Agents on Model Bacterial

Paweł Kowalczyk, Monika Wilk, Parul Parul, Mateusz Szymczak, Karol Kramkowski, Stanisława Raj, Grzegorz Skiba, Dorota Sulejczak, Patrycja Kleczkowska, Ryszard Ostaszewski

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
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  7. Article
  8. Synthesis and Antimicrobial Activity of the PathogenicInternational journal of molecular sciences · 2023
    Article
  9. Aluminium(III) Oxide-The Silent Killer of Bacteria.Molecules (Basel, Switzerland) · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Functionalised Anodised Aluminium Oxide as a Biocidal Agent.International journal of molecular sciences · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Paweł KowalczykDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.ORCID 0000-0003-4025-3750
Monika WilkInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Parul ParulInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0002-1723-2882
Mateusz SzymczakDepartment of Molecular Virology, Faculty of Biology, Institute of Microbiology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0003-4056-7792
Karol KramkowskiDepartment of Physical Chemistry, Medical University of Bialystok, Kilińskiego 1 Str., 15-089 Białystok, Poland.
Stanisława RajDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.
Grzegorz SkibaDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.
Dorota SulejczakDepartment of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.ORCID 0000-0002-1697-8164
Patrycja KleczkowskaCentre for Preclinical Research (CBP), Department of Pharmacodynamics, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.ORCID 0000-0002-8389-0920
Ryszard OstaszewskiInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0002-3032-196X
Institute of Organic Chemistry · PLKielanowski Institute of Animal Physiology and Nutrition · PLMedical University of Białystok · PLMedical University of Warsaw · PLMossakowski Medical Research Institute, Polish Academy of Sciences · PLUniversity of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work presents the successful synthesis of a library of novel peptidomimetics via Ugi multicomponent reaction. Most of these peptidomimetics contain differently substituted aminocoumarin; 7-amino-4-methylcoumarin and 7-amino-4-(trifluoromethyl) coumarin. Inspired by the biological properties of coumarin derivatives and peptidomimetics, we proposed the synthesis of coumarin incorporated peptidomimetics. We studied the potential of synthesized compounds as antimicrobial drugs on model

Indexed as

coumarin derivativesDNA-N-glycosylaseFpg protein-formamidopyrimidinelipopolysaccharide (LPS)oxidative stressUgi multicomponent reaction

Identifiers

PMID34640121
PMCPMC8510199
OpenAlexW3202646876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.