Evidence map›Paper›PMID 34639744›Full record

ReviewInternational journal of environmental research and public health2021

Environment in Children's Health: A New Challenge for Risk Assessment.

Francesca Mastorci, Nunzia Linzalone, Lamia Ait-Ali, Alessandro Pingitore

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Early-life NOThe Lancet regional health. Western Pacific · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. [Pediatric thunderstorm asthma in China: epidemiological characteristics and comprehensive management].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Francesca MastorciBiocomplexity Lab, Clinical Physiology Institute, National Research Council (NRC), Via Moruzzi 1, 56124 Pisa, PI, Italy.ORCID 0000-0002-9415-3715
Nunzia LinzaloneBiocomplexity Lab, Clinical Physiology Institute, National Research Council (NRC), Via Moruzzi 1, 56124 Pisa, PI, Italy.
Lamia Ait-AliBiocomplexity Lab, Clinical Physiology Institute, National Research Council (NRC), Via Moruzzi 1, 56124 Pisa, PI, Italy.
Alessandro PingitoreBiocomplexity Lab, Clinical Physiology Institute, National Research Council (NRC), Via Moruzzi 1, 56124 Pisa, PI, Italy.ORCID 0000-0002-4049-184X
Istituto di Fisiologia Clinica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last few years, many studies have focused on the effects of environmental contaminant exposure during the prenatal period or infancy as predictors of health outcomes in the future. In these time windows, due to their rapid growth, and physiologic and metabolic development, we can observe a higher vulnerability to the effects of environment, with respect to adulthood. The evidence of possible influences, partly mediated by epigenetic mechanisms, involve neurobehavioral responses and immune, endocrine, and respiratory systems, acting directly on the child or indirectly when mediated by placental transfer or breast feeding. In particular, due to a greater intake of air, food, and fluids relative to body weight, crawling behaviors and short stature, the risk of excessive exposure is greater in children. However, data on the long-term implications of early exposures are scarce. Additionally, so that physicians and institutions for child care and assistance of pregnant women can take actions to counteract the effects of chemical pollution (i.e., by educational opportunities), a risk assessment perspective that responds to the biocomplexity of the human being is needed. The present paper provides an overview of physiologic and behavioral characteristics during the perinatal period and in childhood, suggesting in a more integrated way, the need of a new risk-assessment approach to managing chronic disease in pediatric patients.

Indexed as

Child HealthPlacentaAdultChildEnvironmental ExposureFemaleHumansPregnancyRisk Assessmentchildrenenvironmental contaminantsfetalhealthperinatal periodrisk assessment

Identifiers

PMID34639744
PMCPMC8507725
OpenAlexW3203331133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.