Evidence map›Paper›PMID 34639705›Full record

ArticleInternational journal of environmental research and public health2021

E-Cigarette Use, Systemic Inflammation, and Depression.

Kayla Rae Farrell, Emma Karey, Shu Xu, Grace Gibbon, Terry Gordon, Michael Weitzman

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kayla Rae FarrellDepartment of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA.ORCID 0000-0003-2166-2401
Emma KareyDepartment of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA.ORCID 0000-0002-5446-5351
Shu XuDepartment of Biostatistics, School of Global Public Health, New York University, New York, NY 10003, USA.
Grace GibbonDepartment of Epidemiology, School of Global Public Health, New York University, New York, NY 10003, USA.
Terry GordonDepartment of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA.
Michael WeitzmanDepartment of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA.
New York University · US

Funding

TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007324 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CUDDAPAH, SURESH · 1999 to 2025
$5.8M
Air Quality, Child, and Adult Health in Homes Where E-Cigarettes Are SmokedR01HL139239 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON, TERRY, WEITZMAN, MICHAEL LANE · 2017 to 2020
$2.0M
Air Quality, Child, and Adult Health in Homes where Hookahs are SmokedR21ES026996 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEITZMAN, MICHAEL LANE · 2017 to 2018
$466k
NHLBI NIH HHS R01 HL139239NIEHS NIH HHS T32 ES007324
6 · The paper itself

Abstract

backgroundE-cigarette use (vaping) is an emerging public health problem. Depression has been found to be associated with e-cigarette use, and vaping and depression are each associated with elevated systemic inflammation. To date, the role of inflammation in the relationship between vaping and depression has not been explored.

objectiveTo assess the independent associations between e-cigarette use, depression, and inflammation, and to investigate whether the likelihood of depression among current e-cigarette users is associated with systemic inflammation.

methodsNationally representative NHANES data from 2015-2018 were used (

resultsDepression occurred in 16.7% of all e-cigarette users vs. 5.0% of those who never used e-cigarettes (

conclusionWhile a pattern of greater ORs for depression among e-cigarette users with elevated CRP provides provocative findings that might suggest a potential role of inflammation in the association between vaping and depression, we failed to find evidence that inflammation clearly moderates this association. While it is possible that depression among e-cigarette users may be influenced by systemic inflammation, a reproduction of the current study is necessary among a larger cohort to elucidate the effect of inflammation on depression among e-cigarette users.

Indexed as

Electronic Nicotine Delivery SystemsVapingDepressionHumansInflammationNutrition SurveysC-reactive proteindepressione-cigarettesinflammation

Identifiers

PMID34639705
PMCPMC8507884
OpenAlexW3204162415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.