Evidence map›Paper›PMID 34639512›Full record

ArticleInternational journal of environmental research and public health2021

Neonatal Outcomes after Combined Opioid and Nicotine Exposure in Utero: A Scoping Review.

Krystyna R Isaacs, Sravanthi Atreyapurapu, Amal H Alyusuf, David M Ledgerwood, Loretta P Finnegan, Katie H K Chang, Tony X Ma, Yukiko Washio

Open access · goldAbstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Prediction of site-specific pharmacologic therapy among newborns with neonatal opioid withdrawal syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Krystyna R IsaacsBenten Technologies, 9408 Grant Ave Suite 206, Manassas, VA 20110, USA.
Sravanthi AtreyapurapuBenten Technologies, 9408 Grant Ave Suite 206, Manassas, VA 20110, USA.ORCID 0000-0002-1064-1552
Amal H AlyusufBenten Technologies, 9408 Grant Ave Suite 206, Manassas, VA 20110, USA.ORCID 0000-0001-9733-9315
David M LedgerwoodDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Detroit, MI 48201, USA.
Loretta P FinneganExecutive Officer of the College on Problems of Drug Dependence and Finnegan Consulting, Philadelphia, PA 19140, USA.
Katie H K ChangBenten Technologies, 9408 Grant Ave Suite 206, Manassas, VA 20110, USA.
Tony X MaBenten Technologies, 9408 Grant Ave Suite 206, Manassas, VA 20110, USA.ORCID 0000-0003-3092-0572
Yukiko WashioSubstance Use, Gender and Applied Research, RTI International, 3040 E Cornwallis Rd, Durham, NC 27709, USA.ORCID 0000-0002-3882-2953
Benten Technologies (United States) · USRTI International · USWayne State University · US

Funding

SAFE4BOTH integration of mobile technologies with case management (CM) systems provide education, work flow among multiple stakeholders to implement Plan of Safe Care (POSC) for SUD mom and infantsR43DA048673 · NIDA · BENTEN TECHNOLOGIES, INC. · PI MA, TONY XUYEN · 2019 to 2019
$225k
NIDA NIH HHS R43 DA048673NIH HHS 1R43DA04867301A1
6 · The paper itself

Abstract

backgroundThe majority of women who are pregnant with opioid use disorder (OUD) also smoke tobacco but are rarely offered tobacco cessation counseling. While the effects of exposure to opioids and nicotine in utero are well-understood separately, understanding the impact of the combined exposure to these substances on neonatal outcomes is lacking.

methodsA scoping review was conducted using PubMed and Scopus databases for studies addressing the combined exposure to opioids and nicotine during pregnancy published between 1 January 1980 and 9 July 2019. A total of 29 papers met the eligibility criteria for inclusion, with nine being identified as clinical trials (three from the MOTHER study) and two as secondary data analysis of clinical trial data.

resultsNeonatal outcomes for infants who had a combined exposure to opioids and nicotine in utero indicated a reduction in birth weight and birth length. Findings in infants exposed to both nicotine and opioids were mixed with regard to the duration of neonatal abstinence syndrome (NAS), the likelihood of treatment for NAS, doses of medicine used to treat NAS, and NAS scores when compared with infants who had opioid exposure without nicotine.

conclusionsThe combined exposure to nicotine and opioids during pregnancy may lead to a reduction in neonatal birth weight and birth length and more severe NAS signs, compared with opioid use alone, but more research is necessary to identify the minimum dosage and length of nicotine exposure to accurately predict these outcomes.

Indexed as

Neonatal Abstinence SyndromeOpioid-Related DisordersAnalgesics, OpioidBirth WeightFemaleHumansInfantInfant, NewbornNicotinePregnancyAnalgesics, OpioidNicotineneonatal abstinence syndromenicotineopioid use disorderpregnancytobacco exposure

Identifiers

PMID34639512
PMCPMC8508043
OpenAlexW3204345447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.