Evidence map›Paper›PMID 34639510›Full record

SynthesisInternational journal of environmental research and public health2021

Interventions to Improve Medication Adherence in Patients with Schizophrenia or Bipolar Disorders: A Systematic Review and Meta-Analysis.

Elke Loots, Eva Goossens, Toke Vanwesemael, Manuel Morrens, Bart Van Rompaey, Tinne Dilles

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07445802 (Therapeutic Adherence Promotion Program for Severe Mental Illness), which is not on this map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07445802 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Therapeutic Adherence Promotion Program for Severe Mental Illness: the ADHERA Study Protocol

TypeinterventionalSponsorInstituto de Investigación Sanitaria de la Fundación Jiménez DíazRan2026 to 2028Enrolled1,640ConditionsTreatment Adherence and Compliance, Severe Mental Disorders, Bipolar Disorder (BD), Schizophrenia DisorderArmsTelehealth Psychoeducational Adherence Program
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  5. Predictors of adherence to exercise interventions in people with schizophrenia.European archives of psychiatry and clinical neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elke LootsCentre For Research and Innovation in Care (CRIC), Department of Nursing Science and Midwifery, Nurse and Pharmaceutical Care (NuPhaC), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.ORCID 0000-0002-2211-0847
Eva GoossensCentre For Research and Innovation in Care (CRIC), Department of Nursing Science and Midwifery, Nurse and Pharmaceutical Care (NuPhaC), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.
Toke VanwesemaelCentre For Research and Innovation in Care (CRIC), Department of Nursing Science and Midwifery, Nurse and Pharmaceutical Care (NuPhaC), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.ORCID 0000-0003-3030-4024
Manuel MorrensFaculty of Medicine and Health Sciences, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, 2610 Antwerp, Belgium.
Bart Van RompaeyCentre For Research and Innovation in Care (CRIC), Department of Nursing Science and Midwifery, Nurse and Pharmaceutical Care (NuPhaC), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.ORCID 0000-0001-7670-0300
Tinne DillesCentre For Research and Innovation in Care (CRIC), Department of Nursing Science and Midwifery, Nurse and Pharmaceutical Care (NuPhaC), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.ORCID 0000-0003-2817-0944
University of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adherence to prescribed medication regimes improves outcomes for patients with severe mental illness such as schizophrenia or bipolar disorders. The aim of this systematic review and meta-analysis was to compare the effectiveness among interventions to improve medication adherence in patients with schizophrenia or bipolar disorders. Literature published in the last decade was searched for interventions studies to improve adherence in patients with schizophrenia or a bipolar disorder. Interventions were categorised on the basis of type, and the context and effectiveness of the interventions were described. Two review authors independently extracted and assessed data, following criteria outlined by the Cochrane Handbook for Systematic Reviews of Interventions. The GRADEPro (McMaster University, 2020, Ontario, Canada) was used for assessing the quality of the evidence. Twenty-three publications met the selection criteria. Different types of interventions aiming to improve adherence were tested: educational, behavioural, family-based, technological, or a combination of previous types. Meta-analysis could be performed for 10 interventions. When considered separately by subgroups on the basis of intervention type, no significant differences were found in adherence among interventions (

Indexed as

Bipolar DisorderSchizophreniaHumansMedication AdherenceOntarioadherencebipolar disorderscomplianceinterventionsschizophrenia

Identifiers

PMID34639510
PMCPMC8508496
OpenAlexW3204810961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.