Evidence map›Paper›PMID 34639444›Full record

ArticleInternational journal of environmental research and public health2021

Is Medication-Related Osteonecrosis of the Jaws (MRONJ) Associated to Cyclin-Dependent Kinase (CDK) 4/6 Inhibitors? A Word of Cautiousness. Comment on Marcianò et al. Medication-Related Osteonecrosis of the Jaws and CDK4/6 Inhibitors: A Recent Association.

Vittorio Fusco, Manuela Alessio, Pamela Francesca Guglielmini, Maura Vincenti, Antonella Fasciolo, Maura Rossi

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. How we manage medication-related osteonecrosis of the jaw.European journal of medical research · 2024
    Review
  2. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Vittorio FuscoOncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera "SS Antonio e Biagio e Cesare Arrigo", 15121 Alessandria, Italy.
Manuela AlessioStudy CoordinatorOncology Unit, Ospedale "Michele e Pietro Ferrero", 12060 Verduno (CN), Italy.ORCID 0000-0002-9118-9237
Pamela Francesca GuglielminiOncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera "SS Antonio e Biagio e Cesare Arrigo", 15121 Alessandria, Italy.
Maura VincentiOncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera "SS Antonio e Biagio e Cesare Arrigo", 15121 Alessandria, Italy.
Antonella FascioloMaxillofacial Surgery Unit, Azienda Ospedaliera "SS Antonio e Biagio e Cesare Arrigo", 15121 Alessandria, Italy.
Maura RossiOncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera "SS Antonio e Biagio e Cesare Arrigo", 15121 Alessandria, Italy.
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITOspedale San Pietro Fatebenefratelli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marcianò et al. launched an alert in this journal about a possible association between medication-related osteonecrosis of the jaws (MRONJ) and cyclin-dependent kinase (CDK) 4/6 inhibitors in breast cancer patients [...].

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsCyclin-Dependent Kinase 4Cyclin-Dependent KinasesHumansJawPublic HealthBone Density Conservation AgentsCDK4 protein, humanCyclin-Dependent Kinase 4Cyclin-Dependent Kinases

Identifiers

PMID34639444
PMCPMC8508584
OpenAlexW3202288385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.