Evidence map›Paper›PMID 34639225›Full record

ArticleInternational journal of molecular sciences2021

Molecular Imaging of Human Skeletal Myoblasts (huSKM) in Mouse Post-Infarction Myocardium.

Katarzyna Fiedorowicz, Weronika Wargocka-Matuszewska, Karolina A Ambrożkiewicz, Anna Rugowska, Łukasz Cheda, Michał Fiedorowicz, Agnieszka Zimna, Monika Drabik, Szymon Borkowski, Maciej Świątkiewicz and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Katarzyna FiedorowiczInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-3921-8459
Weronika Wargocka-MatuszewskaBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02-089 Warsaw, Poland.ORCID 0000-0002-9579-2295
Karolina A AmbrożkiewiczInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0001-8980-4766
Anna RugowskaFaculty of Biology, Institute of Human Biology and Evolution, Adam Mickiewicz University, 60-479 Poznan, Poland.
Łukasz ChedaBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02-089 Warsaw, Poland.
Michał FiedorowiczMossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.ORCID 0000-0001-5755-3608
Agnieszka ZimnaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0003-3778-4470
Monika DrabikMossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Szymon BorkowskiInstitute of Radioelectronics and Multimedia Technology, Warsaw University of Technology, 00-665 Warsaw, Poland.
Maciej ŚwiątkiewiczMossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.ORCID 0000-0001-8193-6836
Piotr BogorodzkiMossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Paweł GriebMossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.ORCID 0000-0002-6983-7947
Paulina HamankiewiczBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02-089 Warsaw, Poland.
Tomasz J KolanowskiInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0003-3898-8272
Natalia RozwadowskaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0002-5111-0870
Urszula KozłowskaInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Aleksandra KlimczakInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0001-6590-4420
Jerzy KolasińskiKolasiński Clinic, Hair Clinic Poznan, 62-020 Swarzędz, Poland.
Zbigniew RogulskiBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02-089 Warsaw, Poland.
Maciej KurpiszInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.ORCID 0000-0003-3275-3245
Institute of Human Genetics · PLMossakowski Medical Research Institute, Polish Academy of Sciences · PLUniversity of Warsaw · PLWarsaw University of Technology · PLAdam Mickiewicz University in Poznań · PL

Funding

Narodowe Centrum Badań i Rozwoju PBS3/A7/27/2015
6 · The paper itself

Abstract

Current treatment protocols for myocardial infarction improve the outcome of disease to some extent but do not provide the clue for full regeneration of the heart tissues. An increasing body of evidence has shown that transplantation of cells may lead to some organ recovery. However, the optimal stem cell population has not been yet identified. We would like to propose a novel pro-regenerative treatment for post-infarction heart based on the combination of human skeletal myoblasts (huSkM) and mesenchymal stem cells (MSCs). huSkM native or overexpressing gene coding for Cx43 (huSKMCx43) alone or combined with MSCs were delivered in four cellular therapeutic variants into the healthy and post-infarction heart of mice while using molecular reporter probes. Single-Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) performed right after cell delivery and 24 h later revealed a trend towards an increase in the isotopic uptake in the post-infarction group of animals treated by a combination of huSkMCx43 with MSC. Bioluminescent imaging (BLI) showed the highest increase in firefly luciferase (fluc) signal intensity in post-infarction heart treated with combination of huSkM and MSCs vs. huSkM alone (

Indexed as

AnimalsDisease Models, AnimalGenes, ReporterHumansMesenchymal Stem CellsMiceMice, Inbred NODMice, SCIDMolecular ImagingMyoblasts, SkeletalMyocardial InfarctionMyocardiumBioluminescent Imaginghuman skeletal myoblastsMagnetic Resonance Imagingmesenchymal stem cellspromoter reporter geneSingle-Photon Emission Computed Tomography/Computed Tomographytechnetium

Identifiers

PMID34639225
PMCPMC8509689
OpenAlexW3202433705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.