Evidence map›Paper›PMID 34639179›Full record

ArticleInternational journal of molecular sciences2021

Processing and Bypass of a Site-Specific DNA Adduct of the Cytotoxic Platinum-Acridinylthiourea Conjugate by Polymerases Involved in DNA Repair: Biochemical and Thermodynamic Aspects.

Monika Hreusova, Viktor Brabec, Olga Novakova

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Monika HreusovaCzech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ 61265 Brno, Czech Republic.
Viktor BrabecCzech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ 61265 Brno, Czech Republic.ORCID 0000-0002-8233-1393
Olga NovakovaCzech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ 61265 Brno, Czech Republic.ORCID 0000-0001-8653-4836
Czech Academy of Sciences, Institute of Biophysics · CZ

Funding

Grantová Agentura České Republiky 21-27514S
6 · The paper itself

Abstract

DNA-dependent DNA and RNA polymerases are important modulators of biological functions such as replication, transcription, recombination, or repair. In this work performed in cell-free media, we studied the ability of selected DNA polymerases to overcome a monofunctional adduct of the cytotoxic/antitumor platinum-acridinylthiourea conjugate [PtCl(en)(L)](NO

Indexed as

DNA DamageDNA RepairDNA AdductsDNA-Directed DNA PolymeraseDNA ReplicationHumansIntercalating AgentsOrganoplatinum CompoundsUrea1-(2-(acridin-9-ylamino)ethyl)-1,3-dimethylthioureaDNA AdductsDNA-Directed DNA PolymeraseIntercalating AgentsOrganoplatinum CompoundsUreaantitumorcytotoxicDNA polymerasesdrug resistancelesion bypassmetal–intercalatormicroscale thermophoresisplatinum–acridinethermodynamictranslesion synthesis

Identifiers

PMID34639179
PMCPMC8509567
OpenAlexW3201988748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.