Evidence map›Paper›PMID 34639161›Full record

ArticleInternational journal of molecular sciences2021

Amyloid-β Processing in Aged S100B Transgenic Mice Is Sex Dependent.

Krista Minéia Wartchow, Leticia Rodrigues, Izabela Swierzy, Michael Buchfelder, Diogo Onofre de Souza, Carlos-Alberto Gonçalves, Andrea Kleindienst

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Early microglial and astrocyte reactivity in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Review
  4. Review
  5. The S100B Protein: A Multifaceted Pathogenic Factor More Than a Biomarker.International journal of molecular sciences · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Krista Minéia WartchowDepartment of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil.ORCID 0000-0003-4572-3600
Leticia RodriguesDepartment of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil.
Izabela SwierzyDepartment of Neurosurgery, Friedrich-Alexander University, 91054 Erlangen, Germany.
Michael BuchfelderDepartment of Neurosurgery, Friedrich-Alexander University, 91054 Erlangen, Germany.
Diogo Onofre de SouzaDepartment of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil.
Carlos-Alberto GonçalvesDepartment of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil.ORCID 0000-0001-8430-5650
Andrea KleindienstDepartment of Neurosurgery, Friedrich-Alexander University, 91054 Erlangen, Germany.ORCID 0000-0003-4758-0324
Universidade Federal do Rio Grande do Sul · BRFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Calcium-binding protein S100B is involved in neuroregeneration but has also been associated with neurodegeneration. These contrasting effects may result from concentration or duration of exposure. We investigated the effect of long-term increased S100B levels on amyloid-β processing in one-year-old transgenic (tg) mice with 12 copies of the murine S100B gene with specific consideration of sex and specific brain regions. (2) Methods: S100B and amyloid-β 42 (Aβ42) were quantified in serum, cerebrospinal fluid (CSF), adipose tissue, and different brain regions by ELISA in wild-type (wt) and S100Btg mice (each

Indexed as

Protein Processing, Post-TranslationalAdipose TissueAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainFemaleHippocampusMaleMiceMice, TransgenicS100 Calcium Binding Protein beta SubunitSex FactorsAmyloid beta-PeptidesS100b protein, mouseS100 Calcium Binding Protein beta SubunitAlzheimer’s diseaseamyloid-β processingneurodegenerationS100Btransgenic mice

Identifiers

PMID34639161
PMCPMC8509484
OpenAlexW3204395299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.