Evidence map›Paper›PMID 34639142›Full record

ArticleInternational journal of molecular sciences2021

Evaluating Molecular Docking Software for Small Molecule Binding to G-Quadruplex DNA.

Jonathan Dickerhoff, Kassandra R Warnecke, Kaibo Wang, Nanjie Deng, Danzhou Yang

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. GSF-DTA: An Innovative Graph-Sequence Fusion Framework for Drug-Target Affinity Prediction.Interdisciplinary sciences, computational life sciences · 2026
    Article
  3. Article
  4. Article
  5. Investigating Potential 5' UTR G-Quadruplexes Within NRF2 mRNA.Current issues in molecular biology · 2026
    Article
  6. Identification of Small Molecules as Zika Virus Entry Inhibitors.International journal of molecular sciences · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. RSC medicinal chemistry · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Insights into the binding mode of AS1411 aptamer to nucleolin.Frontiers in molecular biosciences · 2022
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jonathan DickerhoffDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA.ORCID 0000-0002-3197-9472
Kassandra R WarneckeDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA.
Kaibo WangDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA.
Nanjie DengDepartment of Chemistry and Physical Sciences, Pace University, 1 Pace Plaza, New York, NY 10038, USA.
Danzhou YangDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 W Stadium Ave, West Lafayette, IN 47907, USA.ORCID 0000-0001-7489-7111
Purdue University West Lafayette · USPace University · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Targeting MYC promoter G-quadruplex for MYC inhibition by IndenoisoquinolinesR01CA177585 · NCI · UNIVERSITY OF ARIZONA · PI SINTIM, HERMAN O, YANG, DANZHOU · 2014 to 2025
$4.0M
Nucleolin recognition of MYC promoter G-quadruplex and its role in MYC regulation by MycG4-ligandsU01CA240346 · NCI · PURDUE UNIVERSITY · PI YANG, DANZHOU · 2020 to 2024
$2.1M
Deutsche Forschungsgemeinschaft 427347592NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA177585NCI NIH HHS U01 CA240346NIH HHS P30CA023168NIH HHS R01CA177585NIH HHS U01CA240346
6 · The paper itself

Abstract

G-quadruplexes are four-stranded nucleic acid secondary structures of biological significance and have emerged as an attractive drug target. The G4 formed in the

Indexed as

G-QuadruplexesMolecular Docking SimulationSoftwareBinding SitesDNAHumansLigandsProto-Oncogene Proteins c-mycSmall Molecule LibrariesDNALigandsProto-Oncogene Proteins c-mycSmall Molecule Librariesdockingdrug designG4-ligandsG-quadruplexpose predictionscoring

Identifiers

PMID34639142
PMCPMC8509811
OpenAlexW3203882266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.