Evidence map›Paper›PMID 34639093›Full record

ArticleInternational journal of molecular sciences2021

Global Proteotoxicity Caused by Human β

Sarah C Good, Katherine M Dewison, Sheena E Radford, Patricija van Oosten-Hawle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Human wild-type and D76N βFASEB bioAdvances · 2023
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sarah C GoodFaculty of Biological Sciences, School of Molecular and Cell Biology & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.
Katherine M DewisonFaculty of Biological Sciences, School of Molecular and Cell Biology & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.ORCID 0000-0002-7196-7687
Sheena E RadfordFaculty of Biological Sciences, School of Molecular and Cell Biology & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.
Patricija van Oosten-HawleFaculty of Biological Sciences, School of Molecular and Cell Biology & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.ORCID 0000-0002-5713-6457
University of Leeds · GB

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Biotechnology and Biological Sciences Research Council BB/M011151/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/P001203/1NIH HHS P40 OD010440Wellcome Trust 094232Wellcome Trust 204963Wellcome Trust 204963/Z/16/Z
6 · The paper itself

Abstract

Aggregation of β

Indexed as

Endoplasmic Reticulum StressLongevityMutationProtein AggregatesUnfolded Protein ResponseAnimalsbeta 2-MicroglobulinCaenorhabditis elegansHeat-Shock ResponseHumansbeta 2-MicroglobulinProtein AggregatesC. elegansER stressextracellularprotein misfoldingproteotoxicitystress responsesystemic amyloidosisUPRERβ2 microglobulin

Identifiers

PMID34639093
PMCPMC8509642
OpenAlexW3202621396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.