Evidence map›Paper›PMID 34639091›Full record

ArticleInternational journal of molecular sciences2021

Changes in Cellular Localization of Inter-Alpha Inhibitor Proteins after Cerebral Ischemia in the Near-Term Ovine Fetus.

Kazuki Hatayama, Boram Kim, Xiaodi Chen, Yow-Pin Lim, Joanne O Davidson, Laura Bennet, Alistair J Gunn, Barbara S Stonestreet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kazuki HatayamaDepartment of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School, Brown University, Providence, RI 02905, USA.
Boram KimDepartment of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School, Brown University, Providence, RI 02905, USA.
Xiaodi ChenDepartment of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School, Brown University, Providence, RI 02905, USA.
Yow-Pin LimProThera Biologics, Inc., Providence, RI 02903, USA.
Joanne O DavidsonDepartment of Physiology, The University of Auckland, Auckland 1142, New Zealand.
Laura BennetDepartment of Physiology, The University of Auckland, Auckland 1142, New Zealand.
Alistair J GunnDepartment of Physiology, The University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0003-0656-7035
Barbara S StonestreetDepartment of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School, Brown University, Providence, RI 02905, USA.ORCID 0000-0002-6532-7683
Brown University · USUniversity of Auckland · NZProvidence College · US

Funding

NIH HHS 1R21NS095130NIH HHS 1R21NS096525NIH HHS 2R01HD057100NIH HHS 2R44 NS084575NIH HHS HRC 17/601
6 · The paper itself

Abstract

Inter-alpha Inhibitor Proteins (IAIPs) are key immunomodulatory molecules. Endogenous IAIPs are present in human, rodent, and sheep brains, and are variably localized to the cytoplasm and nuclei at multiple developmental stages. We have previously reported that ischemia-reperfusion (I/R) reduces IAIP concentrations in the fetal sheep brain. In this study, we examined the effect of I/R on total, cytoplasmic, and nuclear expression of IAIPs in neurons (NeuN

Indexed as

Alpha-GlobulinsAnimalsAnimals, NewbornFemaleFetusHypoxia-Ischemia, BrainMaleMicrogliaNeuronsNeuroprotective AgentsOligodendrogliaSheepSubcellular FractionsAlpha-Globulinsinter-alpha-inhibitorNeuroprotective Agentsbrain injuryhypoxia-ischemiainter-alpha inhibitor proteinsovine fetus

Identifiers

PMID34639091
PMCPMC8509455
OpenAlexW3204132552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.