Evidence map›Paper›PMID 34639072›Full record

ArticleInternational journal of molecular sciences2021

The Natural Pigment Violacein Potentially Suppresses the Proliferation and Stemness of Hepatocellular Carcinoma Cells In Vitro.

Yu Jin Kim, Nayeong Yuk, Hee Jeong Shin, Hye Jin Jung

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Violacein-Loaded Outer Membrane Vesicles fromACS biomaterials science & engineering · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Cells · 2023
    Article
  9. Article
  10. Atorvastatin inhibits the proliferation of MKN45-derived gastric cancer stem cells in a mevalonate pathway-independent manner.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yu Jin KimDepartment of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea.
Nayeong YukDepartment of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Korea.
Hee Jeong ShinDepartment of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea.
Hye Jin JungDepartment of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea.ORCID 0000-0003-3145-9300
Sun Moon University · KR

Funding

Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education NRF-2021R1I1A3050093Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT NRF-2019R1A2C1009033
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a malignant type of primary liver cancer with high incidence and mortality, worldwide. A major challenge in the treatment of HCC is chemotherapeutic resistance. It is therefore necessary to develop novel anticancer drugs for suppressing the growth of HCC cells and overcoming drug resistance for improving the treatment of HCC. Violacein is a deep violet-colored indole derivative that is produced by several bacterial strains, including

Indexed as

Antineoplastic AgentsApoptosisBiological ProductsCarcinoma, HepatocellularCell Cycle CheckpointsCell Line, TumorCell ProliferationCell Self RenewalHumansIndolesLiver NeoplasmsMAP Kinase Signaling SystemNeoplastic Stem CellsProto-Oncogene Proteins c-aktSTAT3 Transcription FactorAntineoplastic AgentsBiological ProductsIndolesProto-Oncogene Proteins c-aktSTAT3 Transcription Factorviolaceinapoptosishepatocellular carcinomaproliferationstemnessviolacein

Identifiers

PMID34639072
PMCPMC8509727
OpenAlexW3202395553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.