Evidence map›Paper›PMID 34639051›Full record

ArticleInternational journal of molecular sciences2021

Pachymic Acid Attenuated Doxorubicin-Induced Heart Failure by Suppressing miR-24 and Preserving Cardiac Junctophilin-2 in Rats.

Nahla N Younis, Alaa Salama, Mohamed A Shaheen, Rana G Eissa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  3. [Pachymic acid promotes brown/beige adipocyte differentiation and lipid metabolism in preadipocytes].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nahla N YounisBiochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Alaa SalamaCardiology Department, Faculty of Human Medicine, Zagazig University, Zagazig 44519, Egypt.
Mohamed A ShaheenHistology and Cell Biology Department, Faculty of Human Medicine, Zagazig University, Zagazig 44519, Egypt.
Rana G EissaBiochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Zagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defects in cardiac contractility and heart failure (HF) are common following doxorubicin (DOX) administration. Different miRs play a role in HF, and their targeting was suggested as a promising therapy. We aimed to target miR-24, a suppressor upstream of junctophilin-2 (JP-2), which is required to affix the sarcoplasmic reticulum to T-tubules, and hence the release of Ca

Indexed as

Gene Expression RegulationAnimalsCardiomegalyDisease Models, AnimalDisease SusceptibilityDoxorubicinHeart FailureHeart Function TestsMembrane ProteinsMicroRNAsMyocytes, CardiacRatsRyanodine Receptor Calcium Release ChannelSignal TransductionTriterpenesDoxorubicinjunctophilinMembrane ProteinsMicroRNAsMIRN24 microRNA, ratpachymic acidRyanodine Receptor Calcium Release ChannelTriterpenesdoxorubicinE–C couplingheart failurelosartanpachymic acidryanodine receptors

Identifiers

PMID34639051
PMCPMC8509247
OpenAlexW3201828107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.