Evidence map›Paper›PMID 34639028›Full record

ArticleInternational journal of molecular sciences2021

Poly ADP Ribose Polymerase Inhibitor Olaparib Targeting Microhomology End Joining in Retinoblastoma Protein Defective Cancer: Analysis of the Retinoblastoma Cell-Killing Effects by Olaparib after Inducing Double-Strand Breaks.

Yuning Jiang, Jason C Yam, Wai Kit Chu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Genomic instability and eye diseases.Advances in ophthalmology practice and research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Yuning JiangDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China.
Jason C YamDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China.
Wai Kit ChuDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0003-2903-3247
Chinese University of Hong Kong · HK

Funding

Health and Medical Research Fund, the Food and Health Bureau, The Government of the Hong Kong Special Administrative Region 07180306Health and Medical Research Fund, the Food and Health Bureau, The Government of the Hong Kong Special Administrative Region PR-HKCH-8The Chinese University of Hong Kong Direct Grant 4054360
6 · The paper itself

Abstract

Retinoblastoma is the most common intraocular cancer in childhood. Loss of function in both copies of the

Indexed as

Antineoplastic AgentsApoptosisCell Line, TumorDNA Breaks, Double-StrandedDNA End-Joining RepairDose-Response Relationship, DrugEtoposideHumansPhthalazinesPiperazinesPoly(ADP-ribose) Polymerase InhibitorsRecombinational DNA RepairRetinoblastomaRetinoblastoma ProteinAntineoplastic AgentsEtoposideolaparibPhthalazinesPiperazinesPoly(ADP-ribose) Polymerase InhibitorsRetinoblastoma ProteinDNA double-strand break repairetoposideolaparibPARP inhibitorretinoblastoma

Identifiers

PMID34639028
PMCPMC8508856
OpenAlexW3204754690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.