Evidence map›Paper›PMID 34638991›Full record

ArticleInternational journal of molecular sciences2021

Selenium and the 15kDa Selenoprotein Impact Colorectal Tumorigenesis by Modulating Intestinal Barrier Integrity.

Jessica A Canter, Sarah E Ernst, Kristin M Peters, Bradley A Carlson, Noelle R J Thielman, Lara Grysczyk, Precious Udofe, Yunkai Yu, Liang Cao, Cindy D Davis and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Selenium in Surgery.Cureus · 2024
    Review
  6. Review
  7. Effects of selenoprotein extracts fromFrontiers in immunology · 2024
    Article
  8. "Alphabet" Selenoproteins: Implications in Pathology.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jessica A CanterDepartment of Biological Sciences, Towson University, Towson, MD 21252, USA.
Sarah E ErnstDepartment of Biological Sciences, Towson University, Towson, MD 21252, USA.
Kristin M PetersDepartment of Biological Sciences, Towson University, Towson, MD 21252, USA.
Bradley A CarlsonMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Noelle R J ThielmanDepartment of Biological Sciences, Towson University, Towson, MD 21252, USA.
Lara GrysczykDepartment of Biological Sciences, Towson University, Towson, MD 21252, USA.
Precious UdofeDepartment of Biological Sciences, Towson University, Towson, MD 21252, USA.
Yunkai YuGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Liang CaoGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cindy D DavisOffice of Dietary Supplements, National Institutes of Health, Bethesda, MD 20817, USA.
Vadim N GladyshevBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Dolph L HatfieldMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Petra A TsujiDepartment of Biological Sciences, Towson University, Towson, MD 21252, USA.
Towson University · USNational Institutes of Health · USCenter for Cancer Research · USHarvard University · US

Funding

Methionine sulfoxide reduction, selenium and agingR01AG021518 · NIA · UNIVERSITY OF NEBRASKA LINCOLN · PI GLADYSHEV, VADIM N. · 2003 to 2018
$5.0M
IDENTITY OF TERMINATOR AND SELENOCYSTEINE UGA CODONSR01GM061603 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GLADYSHEV, VADIM N. · 2000 to 2016
$4.0M
NIA NIH HHS R01 AG021518NIGMS NIH HHS R01 GM061603
6 · The paper itself

Abstract

Selenoproteins play important roles in many cellular functions and biochemical pathways in mammals. Our previous study showed that the deficiency of the 15 kDa selenoprotein (

Indexed as

Aberrant Crypt FociAnimalsAzoxymethaneCarcinogenesisColonic NeoplasmsCytokinesDextran SulfateDietDisease Models, AnimalGene Expression Regulation, NeoplasticIntestinal MucosaMaleMiceMice, KnockoutSelenoproteinsSignal TransductionAzoxymethaneCytokinesDextran SulfateSelenof protein, mouseSelenoproteinsSodium SeleniteTrace Elementsbarrier integritycolon cancerinflammationseleniumSelenofselenoprotein

Identifiers

PMID34638991
PMCPMC8508755
OpenAlexW3204794988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.