Evidence map›Paper›PMID 34638976›Full record

ArticleInternational journal of molecular sciences2021

Drosophila Rab39 Attenuates Lysosomal Degradation.

Zsolt Lakatos, Péter Benkő, Gábor Juhász, Péter Lőrincz

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Insights into human kidney function from the study of Drosophila.Pediatric nephrology (Berlin, Germany) · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zsolt LakatosDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.ORCID 0000-0003-1900-3167
Péter BenkőDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.ORCID 0000-0002-2050-7509
Gábor JuhászDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.ORCID 0000-0001-8548-8874
Péter LőrinczDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.
Eötvös Loránd University · HUSemmelweis University · HU

Funding

Magyar Tudományos Akadémia LP-2014/2Magyar Tudományos Akadémia PPD-2018-222National Research, Development and Innovation Office FK 138851National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00006National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00032National Research, Development and Innovation Office K119842National Research, Development and Innovation Office KKP129797National Research, Development and Innovation Office ÚNKP-20-3-II-ELTE-730
6 · The paper itself

Abstract

Lysosomal degradation, the common destination of autophagy and endocytosis, is one of the most important elements of eukaryotic metabolism. The small GTPases Rab39A and B are potential new effectors of this pathway, as their malfunction is implicated in severe human diseases like cancer and neurodegeneration. In this study, the lysosomal regulatory role of the single Drosophila Rab39 ortholog was characterized, providing valuable insight into the potential cell biological mechanisms mediated by these proteins. Using a de novo CRISPR-generated

Indexed as

AnimalsAnimals, Genetically ModifiedAutophagyCRISPR-Cas SystemsDrosophila melanogasterDrosophila ProteinsEndocytosisLarvaLysosomesPhenotyperab GTP-Binding ProteinsDrosophila Proteinsrab GTP-Binding ProteinsautophagyDrosophilaendocytosislysosomesRab39

Identifiers

PMID34638976
PMCPMC8508792
OpenAlexW3204202464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.