Evidence map›Paper›PMID 34638973›Full record

ArticleInternational journal of molecular sciences2021

Production and Characterization of Chitooligosaccharides: Evaluation of Acute Toxicity, Healing, and Anti-Inflammatory Actions.

Rafael Caetano Lisbôa Castro de Andrade, Nathália Kelly de Araújo, Manoela Torres-Rêgo, Allanny Alves Furtado, Alessandra Daniele-Silva, Weslley de Souza Paiva, Julia Maria de Medeiros Dantas, Nayara Sousa da Silva, Arnóbio Antônio da Silva-Júnior, Marcela Abbott Galvão Ururahy and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Improved Enzymatic Properties of Chitosanase CsnMY002 fromInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Rafael Caetano Lisbôa Castro de AndradeLaboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
Nathália Kelly de AraújoLaboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0000-0001-6429-1538
Manoela Torres-RêgoLaboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0000-0002-8535-1533
Allanny Alves FurtadoLaboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
Alessandra Daniele-SilvaLaboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
Weslley de Souza PaivaLaboratory of Biotechnology of Natural Biopolymers, Department of Biochemistry, Bioscience Center, Federal University of Rio Grande do Norte, Natal 59072-970, Brazil.ORCID 0000-0002-2022-5659
Julia Maria de Medeiros DantasPostgraduate Program in Chemical Engineering, Technology Center, Federal University of Rio Grande do Norte, Natal 59072-970, Brazil.ORCID 0000-0002-9091-5786
Nayara Sousa da SilvaLaboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
Arnóbio Antônio da Silva-JúniorLaboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0000-0002-7516-1787
Marcela Abbott Galvão UrurahyDepartment of Clinical Analysis and Toxicology, College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
Cristiane Fernandes de AssisDepartment of Clinical Analysis and Toxicology, College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0000-0001-7595-5395
Leandro De Santis FerreiraDepartment of Pharmacy, College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0000-0002-8408-5886
Hugo Alexandre Oliveira RochaLaboratory of Biotechnology of Natural Biopolymers, Department of Biochemistry, Bioscience Center, Federal University of Rio Grande do Norte, Natal 59072-970, Brazil.
Matheus de Freitas Fernandes-PedrosaLaboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), College of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0000-0003-4221-9580
Universidade Federal do Rio Grande do Norte · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq - grant number 409911/2016-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES - Finance Code 001
6 · The paper itself

Abstract

The search for promising biomolecules such as chitooligosaccharides (COS) has increased due to the need for healing products that act efficiently, avoiding complications resulting from exacerbated inflammation. Therefore, this study aimed to produce COS in two stages of hydrolysis using chitosanases derived from

Indexed as

3T3 CellsAnimalsAnti-Inflammatory AgentsBacillusBiocompatible MaterialsCell MovementCell SurvivalChitosanCytokinesDisease Models, AnimalEar DiseasesEdemaFemaleFibroblastsGlycoside HydrolasesHydrolysisAnti-Inflammatory AgentsBiocompatible MaterialsChitosanchitosanaseCytokinesGlycoside HydrolasesoligochitosanOligosaccharidesbiocompatibilitychitosanenzymatic hydrolysisin vivo testsoligosaccharides

Identifiers

PMID34638973
PMCPMC8508594
OpenAlexW3204090440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.